Abstract
Background: Breast cancer is a collection of molecularly and clinically distinct neoplastic disease. Recent research has shown the information regarding gene expression in breast cancer could be beneficial in the designing of an optimal treatment plan and may also provide with prognostic information. The creation of tissue microarrays (TMA) allows for the rapid immunohistochemical analysis of thousands of tissue samples in parallel with minimal damage to the original blocks. This study was designed with the application of tissue microarray (TMA) to analyze the afamin status in breast cancer with the hope of elucidating the possible relationship between afamin expressions and breast cancer. Methods: Archival tissue specimens from 106 patients with primary invasive breast cancer were analyzed for afamin expression by immunhistochemical staining with TMA. Results were compared to clinicopathologic data by multivariate analysis. Results: TNM stage has shown significant relationship to the overall 5-year survival rate. However, afamin expression was not significantly related to overall five-year survival. Conclusion: Immunohistochemical staining with TMA was convenient and feasible for analyzing afamin expression status in breast cancer. Our preliminary results show that afamin expression showed no significant prognostic value in breast cancer.
| Original language | English |
|---|---|
| Journal | Asian Journal of Surgery |
| DOIs | |
| Publication status | Accepted/In press - Jan 1 2019 |
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Keywords
- Afamin
- Biomarker
- Breast cancer
- Tissue microarray
ASJC Scopus subject areas
- Surgery
Cite this
Afamin expression in breast cancer. / Wang, Wen Ke; Tsai, Ching Hua; Liu, Yueh Wei; Lai, Chun Chi; Huang, Chao Cheng; Sheen-Chen, Shyr Ming.
In: Asian Journal of Surgery, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Afamin expression in breast cancer
AU - Wang, Wen Ke
AU - Tsai, Ching Hua
AU - Liu, Yueh Wei
AU - Lai, Chun Chi
AU - Huang, Chao Cheng
AU - Sheen-Chen, Shyr Ming
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: Breast cancer is a collection of molecularly and clinically distinct neoplastic disease. Recent research has shown the information regarding gene expression in breast cancer could be beneficial in the designing of an optimal treatment plan and may also provide with prognostic information. The creation of tissue microarrays (TMA) allows for the rapid immunohistochemical analysis of thousands of tissue samples in parallel with minimal damage to the original blocks. This study was designed with the application of tissue microarray (TMA) to analyze the afamin status in breast cancer with the hope of elucidating the possible relationship between afamin expressions and breast cancer. Methods: Archival tissue specimens from 106 patients with primary invasive breast cancer were analyzed for afamin expression by immunhistochemical staining with TMA. Results were compared to clinicopathologic data by multivariate analysis. Results: TNM stage has shown significant relationship to the overall 5-year survival rate. However, afamin expression was not significantly related to overall five-year survival. Conclusion: Immunohistochemical staining with TMA was convenient and feasible for analyzing afamin expression status in breast cancer. Our preliminary results show that afamin expression showed no significant prognostic value in breast cancer.
AB - Background: Breast cancer is a collection of molecularly and clinically distinct neoplastic disease. Recent research has shown the information regarding gene expression in breast cancer could be beneficial in the designing of an optimal treatment plan and may also provide with prognostic information. The creation of tissue microarrays (TMA) allows for the rapid immunohistochemical analysis of thousands of tissue samples in parallel with minimal damage to the original blocks. This study was designed with the application of tissue microarray (TMA) to analyze the afamin status in breast cancer with the hope of elucidating the possible relationship between afamin expressions and breast cancer. Methods: Archival tissue specimens from 106 patients with primary invasive breast cancer were analyzed for afamin expression by immunhistochemical staining with TMA. Results were compared to clinicopathologic data by multivariate analysis. Results: TNM stage has shown significant relationship to the overall 5-year survival rate. However, afamin expression was not significantly related to overall five-year survival. Conclusion: Immunohistochemical staining with TMA was convenient and feasible for analyzing afamin expression status in breast cancer. Our preliminary results show that afamin expression showed no significant prognostic value in breast cancer.
KW - Afamin
KW - Biomarker
KW - Breast cancer
KW - Tissue microarray
UR - http://www.scopus.com/inward/record.url?scp=85074436640&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074436640&partnerID=8YFLogxK
U2 - 10.1016/j.asjsur.2019.09.014
DO - 10.1016/j.asjsur.2019.09.014
M3 - Article
AN - SCOPUS:85074436640
JO - Asian Journal of Surgery
JF - Asian Journal of Surgery
SN - 1015-9584
ER -