Afamin expression in breast cancer

Wen Ke Wang, Ching Hua Tsai, Yueh Wei Liu, Chun Chi Lai, Chao Cheng Huang, Shyr Ming Sheen-Chen

Research output: Contribution to journalArticle

Abstract

Background: Breast cancer is a collection of molecularly and clinically distinct neoplastic disease. Recent research has shown the information regarding gene expression in breast cancer could be beneficial in the designing of an optimal treatment plan and may also provide with prognostic information. The creation of tissue microarrays (TMA) allows for the rapid immunohistochemical analysis of thousands of tissue samples in parallel with minimal damage to the original blocks. This study was designed with the application of tissue microarray (TMA) to analyze the afamin status in breast cancer with the hope of elucidating the possible relationship between afamin expressions and breast cancer. Methods: Archival tissue specimens from 106 patients with primary invasive breast cancer were analyzed for afamin expression by immunhistochemical staining with TMA. Results were compared to clinicopathologic data by multivariate analysis. Results: TNM stage has shown significant relationship to the overall 5-year survival rate. However, afamin expression was not significantly related to overall five-year survival. Conclusion: Immunohistochemical staining with TMA was convenient and feasible for analyzing afamin expression status in breast cancer. Our preliminary results show that afamin expression showed no significant prognostic value in breast cancer.

Original languageEnglish
JournalAsian Journal of Surgery
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Breast Neoplasms
Tissue Array Analysis
Staining and Labeling
Multivariate Analysis
Survival Rate
Gene Expression
Survival
Research
Therapeutics

Keywords

  • Afamin
  • Biomarker
  • Breast cancer
  • Tissue microarray

ASJC Scopus subject areas

  • Surgery

Cite this

Afamin expression in breast cancer. / Wang, Wen Ke; Tsai, Ching Hua; Liu, Yueh Wei; Lai, Chun Chi; Huang, Chao Cheng; Sheen-Chen, Shyr Ming.

In: Asian Journal of Surgery, 01.01.2019.

Research output: Contribution to journalArticle

@article{461bb1fbb0204dc49e62e12a04ed1531,
title = "Afamin expression in breast cancer",
abstract = "Background: Breast cancer is a collection of molecularly and clinically distinct neoplastic disease. Recent research has shown the information regarding gene expression in breast cancer could be beneficial in the designing of an optimal treatment plan and may also provide with prognostic information. The creation of tissue microarrays (TMA) allows for the rapid immunohistochemical analysis of thousands of tissue samples in parallel with minimal damage to the original blocks. This study was designed with the application of tissue microarray (TMA) to analyze the afamin status in breast cancer with the hope of elucidating the possible relationship between afamin expressions and breast cancer. Methods: Archival tissue specimens from 106 patients with primary invasive breast cancer were analyzed for afamin expression by immunhistochemical staining with TMA. Results were compared to clinicopathologic data by multivariate analysis. Results: TNM stage has shown significant relationship to the overall 5-year survival rate. However, afamin expression was not significantly related to overall five-year survival. Conclusion: Immunohistochemical staining with TMA was convenient and feasible for analyzing afamin expression status in breast cancer. Our preliminary results show that afamin expression showed no significant prognostic value in breast cancer.",
keywords = "Afamin, Biomarker, Breast cancer, Tissue microarray",
author = "Wang, {Wen Ke} and Tsai, {Ching Hua} and Liu, {Yueh Wei} and Lai, {Chun Chi} and Huang, {Chao Cheng} and Sheen-Chen, {Shyr Ming}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.asjsur.2019.09.014",
language = "English",
journal = "Asian Journal of Surgery",
issn = "1015-9584",
publisher = "Elsevier Taiwan LLC",

}

TY - JOUR

T1 - Afamin expression in breast cancer

AU - Wang, Wen Ke

AU - Tsai, Ching Hua

AU - Liu, Yueh Wei

AU - Lai, Chun Chi

AU - Huang, Chao Cheng

AU - Sheen-Chen, Shyr Ming

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Breast cancer is a collection of molecularly and clinically distinct neoplastic disease. Recent research has shown the information regarding gene expression in breast cancer could be beneficial in the designing of an optimal treatment plan and may also provide with prognostic information. The creation of tissue microarrays (TMA) allows for the rapid immunohistochemical analysis of thousands of tissue samples in parallel with minimal damage to the original blocks. This study was designed with the application of tissue microarray (TMA) to analyze the afamin status in breast cancer with the hope of elucidating the possible relationship between afamin expressions and breast cancer. Methods: Archival tissue specimens from 106 patients with primary invasive breast cancer were analyzed for afamin expression by immunhistochemical staining with TMA. Results were compared to clinicopathologic data by multivariate analysis. Results: TNM stage has shown significant relationship to the overall 5-year survival rate. However, afamin expression was not significantly related to overall five-year survival. Conclusion: Immunohistochemical staining with TMA was convenient and feasible for analyzing afamin expression status in breast cancer. Our preliminary results show that afamin expression showed no significant prognostic value in breast cancer.

AB - Background: Breast cancer is a collection of molecularly and clinically distinct neoplastic disease. Recent research has shown the information regarding gene expression in breast cancer could be beneficial in the designing of an optimal treatment plan and may also provide with prognostic information. The creation of tissue microarrays (TMA) allows for the rapid immunohistochemical analysis of thousands of tissue samples in parallel with minimal damage to the original blocks. This study was designed with the application of tissue microarray (TMA) to analyze the afamin status in breast cancer with the hope of elucidating the possible relationship between afamin expressions and breast cancer. Methods: Archival tissue specimens from 106 patients with primary invasive breast cancer were analyzed for afamin expression by immunhistochemical staining with TMA. Results were compared to clinicopathologic data by multivariate analysis. Results: TNM stage has shown significant relationship to the overall 5-year survival rate. However, afamin expression was not significantly related to overall five-year survival. Conclusion: Immunohistochemical staining with TMA was convenient and feasible for analyzing afamin expression status in breast cancer. Our preliminary results show that afamin expression showed no significant prognostic value in breast cancer.

KW - Afamin

KW - Biomarker

KW - Breast cancer

KW - Tissue microarray

UR - http://www.scopus.com/inward/record.url?scp=85074436640&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074436640&partnerID=8YFLogxK

U2 - 10.1016/j.asjsur.2019.09.014

DO - 10.1016/j.asjsur.2019.09.014

M3 - Article

AN - SCOPUS:85074436640

JO - Asian Journal of Surgery

JF - Asian Journal of Surgery

SN - 1015-9584

ER -