10 Citations (Scopus)

Abstract

The association between the long-term use of proton pump inhibitors (PPIs) and the risks of various diseases remains controversial. Therefore, the primary objective of this study was to quantify the associations as presented in the literature and to also provide this information to healthcare professionals and patients about their potentially adverse effects. In July 2016, we searched through Medline (PubMed), Embase, and the Cochrane Library from inception using common keywords. We included observational studies that provided risk estimates on the long-term use of PPIs and their adverse effects. Overall, 43 studies were included in the systematic review, of which 28 studies were also included in the random effect meta-analysis. Odds of community-acquired pneumonia, hip fracture, and colorectal cancer were 67% [odds ratio (OR)=1.67; 95% confidence interval (CI): 1.04-2.67], 42% (OR=1.42; 95% CI: 1.33-1.53), and 55% (OR=1.55; 95% CI: 0.88-2.73) higher in patients with long-term PPIs use compared with patients who did not use PPIs. Although the use of PPIs provides short-term health benefits, their prolonged use is associated with minor and also potentially major adverse health outcomes. Hence, we strongly recommend that the prescription of PPIs should be done with caution to improve the medication's efficacy and patients' safety.

Original languageEnglish
Pages (from-to)1395-1405
Number of pages11
JournalEuropean Journal of Gastroenterology and Hepatology
Volume30
Issue number12
Early online dateJul 19 2018
DOIs
Publication statusPublished - Dec 1 2018

Fingerprint

Proton Pump Inhibitors
Meta-Analysis
Odds Ratio
Confidence Intervals
Hip Fractures
Insurance Benefits
Patient Safety
PubMed
Libraries
Observational Studies
Prescriptions
Colorectal Neoplasms
Pneumonia
Delivery of Health Care
Health

Keywords

  • Alzheimer
  • cancer
  • cardiac disease
  • gastroesophageal reflux disease
  • kidney disease
  • proton pump inhibitors

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Adverse outcomes of long-term use of proton pump inhibitors : a systematic review and meta-analysis. / Islam, Md Mohaimenul; Poly, Tahmina N; Walther, Bruno A; Dubey, Navneet K; Anggraini Ningrum, Dina N; Shabbir, Syed-Abdul; Jack Li, Yu-Chuan.

In: European Journal of Gastroenterology and Hepatology, Vol. 30, No. 12, 01.12.2018, p. 1395-1405.

Research output: Contribution to journalReview article

Islam, Md Mohaimenul ; Poly, Tahmina N ; Walther, Bruno A ; Dubey, Navneet K ; Anggraini Ningrum, Dina N ; Shabbir, Syed-Abdul ; Jack Li, Yu-Chuan. / Adverse outcomes of long-term use of proton pump inhibitors : a systematic review and meta-analysis. In: European Journal of Gastroenterology and Hepatology. 2018 ; Vol. 30, No. 12. pp. 1395-1405.
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