Advanced glycation end products (AGEs) in relation to atherosclerotic lipid profiles in middle-aged and elderly diabetic patients

Jin Biou Chang, Nain Feng Chu, Jhu Ting Syu, An Tsz Hsieh, Yi Ren Hung

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objectives. To evaluate the association between AGEs and atherosclerotic lipid profiles among aging diabetic patients in Taiwan. Design and Methods. After age and gender matching, we selected 207 diabetic subjects and 174 diabetic subjects with proteinuria. Lipid profiles, including total cholesterol (TC), triglycerides (TG), high density cholesterol-lipoprotein (HDL-C) and low density lipoprotein-cholesterol (LDL-C) were measured using standard methods. AGEs were measured with the immunoassay method. Results: In general, males were heavier; however, females had higher AGEs, fasting glucose (GLU), TC, HDL-C and LDL-C levels than males, and had higher TC/HDL-C, LDL-C/HDL-C, and TG/HDL-C ratios compared to males. AGEs were more strongly correlated with TG levels and TCL/LDL-C, LDL-C/HDL-C and TG/HDL-C ratios when compared to glucose or hemoglobin A1c. Subjects had higher AGEs levels (≧ 2.0 AU) with more adverse lipid profiles. Conclusion: AGEs seem to be a good biomarker to evaluate the association between diabetes and atherosclerotic disorders in aging diabetes.

Original languageEnglish
Article number228
JournalLipids in Health and Disease
Volume10
DOIs
Publication statusPublished - 2011

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Advanced Glycosylation End Products
LDL Cholesterol
Lipids
Triglycerides
HDL Cholesterol
Medical problems
Aging of materials
Association reactions
Glucose
Biomarkers
Taiwan
Proteinuria
Immunoassay
Fasting
Hemoglobins
Cholesterol

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Advanced glycation end products (AGEs) in relation to atherosclerotic lipid profiles in middle-aged and elderly diabetic patients. / Chang, Jin Biou; Chu, Nain Feng; Syu, Jhu Ting; Hsieh, An Tsz; Hung, Yi Ren.

In: Lipids in Health and Disease, Vol. 10, 228, 2011.

Research output: Contribution to journalArticle

Chang, Jin Biou ; Chu, Nain Feng ; Syu, Jhu Ting ; Hsieh, An Tsz ; Hung, Yi Ren. / Advanced glycation end products (AGEs) in relation to atherosclerotic lipid profiles in middle-aged and elderly diabetic patients. In: Lipids in Health and Disease. 2011 ; Vol. 10.
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