Adults with late stage 3 chronic kidney disease are at high risk for prevalent silent brain infarction: A population-based study

Chia Chi Chou, Li Ming Lien, Wei Hung Chen, Mai Szu Wu, Shiue Ming Lin, Hou Chang Chiu, Hung Yi Chiou, Chyi Huey Bai

Research output: Contribution to journalArticle

22 Citations (Scopus)


Background and Purpose-The close relationship between stroke and chronic kidney disease (CKD) has been well-documented. However, few studies have focused on silent brain infarction (SBI) in CKD. We investigated the prevalence of SBI in different stages of CKD. Methods-We included 1312 participants aged 30 to 93 years who came from either a random sample of residents or from a group of physically examined subjects in the same community. Basic information, clinical evaluations, laboratory tests, and MRI images were assessed. Subjects were divided into groups 1, 2, 3a, and 3b, corresponding to the estimated glomerular filtration rate (eGFR) levels of 90.0, 60.0 to 89.9, 45.0 to 59.9, and 30.0 to 44.9 mL/min/1.73 m. Results-The crude prevalence was 4.7%: 2.6% (20 of 759 subjects) in group 1; 6.3% (32 of 506) in group 2; 12.9% (4 of 31) in group 3a; and 37.5% (6 of 16) in group 3b (P

Original languageEnglish
Pages (from-to)2120-2125
Number of pages6
Issue number8
Publication statusPublished - Aug 2011
Externally publishedYes



  • chronic kidney disease
  • magnetic resonance imaging
  • silent brain infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing

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