Adsorption of peptides to poly(D,L-lactide-co-glycolide): 2. Effect of solution properties on the adsorption

Tsuimin Tsai, Rahul C. Mehta, Patrick P. DeLuca

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The effect of pH, ionic strength, polarity and temperature on the adsorption of three peptides to poly(D,L-lactide-co-glycolide) (PLGA) was evaluated. Maximum adsorption was found near the pi of the peptide for salmon calcitonin (sCT), triptorelin (DP) and a peptide comprising the 8-22 amino acid portion of sCT. For sCT, almost no adsorption was observed at pH <6 while there was complete depletion at pH 10. Increase in NaCl concentration enhanced the adsorption of sCT and DP. The dependency on solvent ionic strength and polarity suggested that hydrophobic interactions were playing an important role in the adsorption process. The net adsorption of sCT and DP was greater at 22°C than at 4°C or 37°C.

Original languageEnglish
Pages (from-to)43-52
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume127
Issue number1
DOIs
Publication statusPublished - Jan 15 1996

Keywords

  • Adsorption
  • Desorbtion
  • L-lactide-co-glycolide)
  • Peptide-polymer interaction
  • Poly(D
  • Salmon calcitonin

ASJC Scopus subject areas

  • Pharmaceutical Science

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