Adsorption of peptides to poly(D,L-lactide-co-glycolide): 1. Effect of physical factors on the adsorption

Tsuimin Tsai, Rahul C. Mehta, Patrick P. DeLuca

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Four peptides, salmon calcitonin (sCT), the 8-22 amino acid portion of sCT (CT15), an LHRH superagonist, triptorelin (DP) and a somatostatin analogue (RC160) were studied for adsorption to poly(D,L-lactide-co-glycolide) (PLGA) as a function of peptide and polymer concentration. The adsorption of sCT and DP to the polymer showed a primary transient-equilibrium followed by a more rapid and extensive adsorption without reaching a concentration plateau for sCT which occurred earlier with higher peptide concentration. The amount of adsorption for CT15 was much lower than that for sCT and DP and RC160 showed no adsorption. Adsorption isotherms of sCT and DP were fitted to a Langmuir-type of relationship and the monolayer concentration was close to that observed in the kinetic studies or that calculated by the theoretical approach.

Original languageEnglish
Pages (from-to)31-42
Number of pages12
JournalInternational Journal of Pharmaceutics
Volume127
Issue number1
DOIs
Publication statusPublished - Jan 15 1996

Keywords

  • Langmuir isotherms
  • Peptide-polymer interaction
  • Poly(D,L-lactide-co-glycolide)

ASJC Scopus subject areas

  • Pharmaceutical Science

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