Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II

K. M. Tewey, T. C. Rowe, L. Yang, B. D. Halligan, Leroy-Fong Liu

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Abstract

Adriamycin (doxorubicin), a potent antitumor drug in clinical use, interacts with nucleic acids and cell membranes, but the molecular basis for its antitumor activity is unknown. Similar to a number of intercalative antitumor drugs and nonintercalative epipodophyllotoxins (VP-16 and VM-26), adriamycin has been shown to induce single- and double-strand breaks in DNA. These strand breaks are unusual because a cavalently bound protein appears to be associated with each broken phosphodiester bond. In studies in vitro, mammalian DNA topoisomerase II mediates DNA damage by adriamycin and other related antitumor drugs.

Original languageEnglish
Pages (from-to)466-468
Number of pages3
JournalScience
Volume226
Issue number4673
Publication statusPublished - 1984
Externally publishedYes

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Cite this

Tewey, K. M., Rowe, T. C., Yang, L., Halligan, B. D., & Liu, L-F. (1984). Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science, 226(4673), 466-468.