ADRA1A gene is associated with BMI in chronic schizophrenia patients exposed to antipsychotics

Yun-Ru Liu, El-Wui Loh, Tsuo-Hung Lan, Shuo-Fei Chen, Yen-Hsin Yu, Yung-Han Chang, Chun-Jung Huang, Tsung-Ming Hu, Keh-Ming Lin, Yu-Tung Yao, Hsien-Jane Chiu

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22 Citations (Scopus)

Abstract

Noradrenaline and adrenaline are neurotransmitters of the sympathetic nervous system that interact with various adrenergic receptor (ADR) subtypes, and this regulates the basal metabolic rate, thermogenesis and efficiency of energy utilization. We examined a possible role of the gene coding for ADRA1A receptor in weight gain in schizophrenia subjects exposed to antipsychotics. A total of 401 schizophrenia in-patients treated with antipsychotics for 2 years were recruited and a final 394 DNA samples were genotyped. Their body mass indexes (BMIs) were recorded for 12 months and parameterized to be correlated in regression. Among the 58 single-nucleotide polymorphisms (SNPs) genotyped, 44 valid SNPs, which had minor allele frequency 0.03, were analyzed in statistics. Linear regression model with age, gender, diabetes, use of typical antipsychotics and use of atypical antipsychotics as covariates, with or without gender interaction, showed evidence of associations between the ADRA1A gene and BMI. Most of the SNPs associated with BMI are located in the promoter and intron regions, and being female appeared to enhance the gene effect. Our study suggests that the ADRA1A gene is involved in weight gain among schizophrenia patients treated with antipsychotics. Further molecular dissection of the ADRA1A gene warrants better understanding on weight gain mechanisms in schizophrenia. © 2010 Nature Publishing Group All rights reserved.
Original languageEnglish
Pages (from-to)30-39
Number of pages10
JournalPharmacogenomics Journal
Volume10
Issue number1
DOIs
Publication statusPublished - 2010
Externally publishedYes

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Keywords

  • ADR
  • ADRA1A gene
  • Antipsychotics
  • BMI
  • Obesity
  • Schizophrenia
  • alpha 1A adrenergic receptor
  • atypical antipsychotic agent
  • neuroleptic agent
  • adult
  • article
  • body mass
  • controlled study
  • diabetes mellitus
  • DNA determination
  • female
  • gene frequency
  • gene interaction
  • genetic association
  • genotype
  • human
  • intron
  • major clinical study
  • male
  • pharmacogenetics
  • priority journal
  • promoter region
  • schizophrenia
  • side effect
  • single nucleotide polymorphism
  • weight gain
  • Adult
  • Aged
  • Aged, 80 and over
  • Antipsychotic Agents
  • Base Sequence
  • Body Mass Index
  • Female
  • Humans
  • Linkage Disequilibrium
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Prospective Studies
  • Receptors, Adrenergic, alpha-1
  • Weight Gain

Cite this

Liu, Y-R., Loh, E-W., Lan, T-H., Chen, S-F., Yu, Y-H., Chang, Y-H., Huang, C-J., Hu, T-M., Lin, K-M., Yao, Y-T., & Chiu, H-J. (2010). ADRA1A gene is associated with BMI in chronic schizophrenia patients exposed to antipsychotics. Pharmacogenomics Journal, 10(1), 30-39. https://doi.org/10.1038/tpj.2009.55