ADP-ribosylating bacterial toxins: Pseudomonas exotoxin A

Tso Ling Chen, Lee Chung Lin, Jaulang Hwang, Chia Po Lin

Research output: Contribution to journalArticle

Abstract

It is well known that a number of toxins produced by bacteria exert their action by ADP-ribosylating reaction to certain proteins which are essential for normal eukaryotic cellular functions. Most of these toxins are composed of two moieties, A and B. The B moiety mediates the binding to the specific receptor on the surface of toxin-sensitive cells, while the A moiety is responsible for the enzymatic ADP-ribosylating activity. Pseudomonas exotoxin A (PEA) is the most toxic component of the extracellular products produced by Pseudomonas aeruginosa. The three domain model of PEA has been well established : domain I, domain II, and domain III exerting binding, translocation, and ADP-ribosylating activities, respectively. Because of the cytotoxic ADP-ribosylating nature of PEA, it has been suggested as a good candidate in the preparation of immunotoxins. In this minireview article, we discuss the structure and function of the bacterial ADP-ribosylating toxins including PEA and compare the differences particularly between PEA and other valevant toxins.

Original languageEnglish
Pages (from-to)111-114
Number of pages4
JournalJournal of Food and Drug Analysis
Volume4
Issue number2
Publication statusPublished - Jun 1996
Externally publishedYes

Fingerprint

bacterial toxins
Bacterial Toxins
exotoxins
Pseudomonas
Adenosine Diphosphate
toxins
Bacterial Structures
Immunotoxins
Poisons
Pseudomonas aeruginosa
Pseudomonas aeruginosa toxA protein
Bacteria
receptors
bacteria
Proteins
proteins
cells

Keywords

  • ADP-ribosylation
  • Bacterial toxins
  • Pseudomonas exotoxin A (PEA)

ASJC Scopus subject areas

  • Food Science
  • Pharmacology

Cite this

Chen, T. L., Lin, L. C., Hwang, J., & Lin, C. P. (1996). ADP-ribosylating bacterial toxins: Pseudomonas exotoxin A. Journal of Food and Drug Analysis, 4(2), 111-114.

ADP-ribosylating bacterial toxins : Pseudomonas exotoxin A. / Chen, Tso Ling; Lin, Lee Chung; Hwang, Jaulang; Lin, Chia Po.

In: Journal of Food and Drug Analysis, Vol. 4, No. 2, 06.1996, p. 111-114.

Research output: Contribution to journalArticle

Chen, TL, Lin, LC, Hwang, J & Lin, CP 1996, 'ADP-ribosylating bacterial toxins: Pseudomonas exotoxin A', Journal of Food and Drug Analysis, vol. 4, no. 2, pp. 111-114.
Chen TL, Lin LC, Hwang J, Lin CP. ADP-ribosylating bacterial toxins: Pseudomonas exotoxin A. Journal of Food and Drug Analysis. 1996 Jun;4(2):111-114.
Chen, Tso Ling ; Lin, Lee Chung ; Hwang, Jaulang ; Lin, Chia Po. / ADP-ribosylating bacterial toxins : Pseudomonas exotoxin A. In: Journal of Food and Drug Analysis. 1996 ; Vol. 4, No. 2. pp. 111-114.
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