Adjuvant tamoxifen influences the lipid profile in breast cancer patients

Che Lin, Li Sheng Chen, Shou Jen Kuo, Dar Ren Chen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Currently there is a debate regarding whether tamoxifen used in breast cancer has an impact on lipid profiles. The aim of this study was to determine whether tamoxifen has an impact on the serum lipid profile in Taiwanese women. Patients and Methods: Data of 109 patients were collected from the routine clinical follow-up for women with hormone receptor-positive breast cancer who were treated between July 2005 and March 2008. These patients were divided into 2 subgroups, based on their tumor grade and lymph node status. Subgroup 1 patients had tumor grade I/II and a negative lymph node status. Those patients with tumor grade III or a positive lymph node status were defined as subgroup 2. Results: In the 109 patients, the mean serum total cholesterol (TC) levels after tamoxifen treatment, as well as the serum low-density lipoprotein cholesterol (LDL-C) levels, were lower than the baseline levels, with statistically significant differences. Treatment with tamoxifen lowered the serum TC and LDL-C levels in both subgroups. Conclusions: The results indicate that tamoxifen has an impact on the serum lipid profile of breast cancer patients in Taiwan. Physicians should follow up the lipid profile in these patients.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalBreast Care
Volume9
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Tamoxifen
Breast Neoplasms
Lipids
Serum
Lymph Nodes
LDL Cholesterol
Cholesterol
Neoplasms
Taiwan
Hormones
Physicians
Therapeutics

Keywords

  • Breast cancer
  • Lipid profile
  • Low-density lipoprotein cholesterol
  • Metabolism
  • Tamoxifen
  • Total cholesterol

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Adjuvant tamoxifen influences the lipid profile in breast cancer patients. / Lin, Che; Chen, Li Sheng; Kuo, Shou Jen; Chen, Dar Ren.

In: Breast Care, Vol. 9, No. 1, 2014, p. 35-39.

Research output: Contribution to journalArticle

Lin, Che ; Chen, Li Sheng ; Kuo, Shou Jen ; Chen, Dar Ren. / Adjuvant tamoxifen influences the lipid profile in breast cancer patients. In: Breast Care. 2014 ; Vol. 9, No. 1. pp. 35-39.
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