Adjunctive input to the nuclear thyroid hormone receptor from the cell surface receptor for the hormone

Paul J. Davis, Hung Yun Lin, Heng Yuan Tang, Faith B. Davis, Shaker A. Mousa

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

At thyroid hormone response elements on specific genes, complexes of nuclear thyroid hormone receptors (TRs) and 3,5,3'-triiodo-L-thyronine (T 3), coactivator or corepressor nucleoproteins, and histone acetylases or deacetylases mediate genomic effects of the hormone. Nongenomic effects of the hormone are those whose initiation does not primarily depend upon formation of the TR-T3 complex. Among the nongenomic effects of thyroid hormone are a set of actions initiated at a cell surface receptor on integrin αvβ3 that are relevant to a) intracellular trafficking of proteins, including TRβ1, b) serine phosphorylation and acetylation of this nuclear receptor, c) assembly within the nucleus of complexes of coactivators and corepressor, and d) transcription of specific genes, including that for TRβ1. These actions initiated at αvβ3 are reviewed here and appear to be adjunctive to the genomic actions of the TR-T3 complex.

Original languageEnglish
Pages (from-to)1503-1509
Number of pages7
JournalThyroid
Volume23
Issue number12
DOIs
Publication statusPublished - Dec 1 2013

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Thyroid Hormone Receptors
Cell Surface Receptors
Cytoplasmic and Nuclear Receptors
CD3 Antigens
Co-Repressor Proteins
Thyroid Hormones
Thyronines
Hormones
Histone Acetyltransferases
Nucleoproteins
Histone Deacetylases
Response Elements
Protein Transport
Acetylation
Integrins
Serine
Genes
Phosphorylation

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Adjunctive input to the nuclear thyroid hormone receptor from the cell surface receptor for the hormone. / Davis, Paul J.; Lin, Hung Yun; Tang, Heng Yuan; Davis, Faith B.; Mousa, Shaker A.

In: Thyroid, Vol. 23, No. 12, 01.12.2013, p. 1503-1509.

Research output: Contribution to journalReview article

Davis, Paul J. ; Lin, Hung Yun ; Tang, Heng Yuan ; Davis, Faith B. ; Mousa, Shaker A. / Adjunctive input to the nuclear thyroid hormone receptor from the cell surface receptor for the hormone. In: Thyroid. 2013 ; Vol. 23, No. 12. pp. 1503-1509.
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