Adjunctive 17β-estradiol administration reduces infarct size by altered expression of canine myocardial connexin43 protein

Tsung-Ming Lee, Mei S. Lin, Tsai F. Chou, Chang H. Tsai, Nen Chung Chang

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

Background: Traffic of potentially harmful cytosolic messengers through gap junctions might cause increased injury during ischemia. The present study was to determine whether the infarct size-reducing effect of adjunctive estradiol administration prior to reperfusion is associated with an attenuated expression of connexin43 at the border of infarction in a canine model. Methods: Experiments were performed in 48 dogs (n=16 each group), assigned to receive either vehicle (control group), 17β-estradiol administered before coronary occlusion (early group), or 3 min before coronary reperfusion following 60-min ischemia (late group). Changes in the amount of phosphorylated connexin43 were measured by Western blot. Results: Infarct size was significantly larger in the control (38±7% of area at risk) than in the supplemented groups (16±6% in the early group; 16±8% in the late group, P

Original languageEnglish
Pages (from-to)109-117
Number of pages9
JournalCardiovascular Research
Volume63
Issue number1
DOIs
Publication statusPublished - Jul 1 2004

Keywords

  • Connexin43
  • Contraction band necrosis
  • Estradiol
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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