Adiponectin gene polymorphisms and obesity increase the susceptibility to arsenic-related renal cell carcinoma

Yu Mei Hsueh, Wei Jen Chen, Ying Chin Lin, Chao Yuan Huang, Horng Sheng Shiue, Shu Mei Yang, Pui Lam Ao, Yeong Shiau Pu, Chien Tien Su

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Our recent study found that high urinary total arsenic levels were associated with renal cell carcinoma (RCC). Recent studies demonstrated that low circulating adiponectin was related to RCC. The aim of the present study was to explore the relationship between adiponectin gene (ADIPOQ) polymorphisms and RCC and investigate whether individuals with an ADIPOQ risk genotype, obesity, and high urinary total arsenic levels have a modified odds ratio (OR) of RCC. A total of 389 RCC patients and 389 age- and sex-matched controls were recruited between November 2006 and December 2012 in Taiwan. Image-guided biopsy or surgical resection of renal tumors was performed to pathologically verify RCC. Genomic DNA was used to examine the genotypes of the ADIPOQ rs182052, ADIPOQ rs2241766, ADIPOQ rs1501299, and ADIPOQ rs1063539 SNPs by PCR-RFLP. HPLC-HG-AAS was used to measure the concentrations of urinary arsenic species. Participants with the ADIPOQ rs182052 G/A+A/A genotype had a significantly higher OR of RCC compared with those with the ADIPOQ rs182052 G/G genotype. The OR (95% confidence interval [CI]) was 1.70 (1.23–2.36). The OR of RCC for the combined effect of high urinary total arsenic levels and obesity, which was dose-dependent, in individuals with the ADIPOQ rs182052 G/A+A/A genotype was 9.33 (3.85–22.62). The present study found significant combined effects of obesity and the ADIPOQ rs182052 G/A+A/A genotype on the arsenic-related risk of RCC in a population with low arsenic exposure. Arsenic exposure, obesity, and the ADIPOQ rs182052 polymorphism could be predictors of a higher OR of RCC.

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalToxicology and Applied Pharmacology
Volume350
DOIs
Publication statusPublished - Jul 1 2018

Fingerprint

Adiponectin
Arsenic
Polymorphism
Renal Cell Carcinoma
Obesity
Genes
Cells
Genotype
Odds Ratio
Biopsy
Image-Guided Biopsy
Tumors
Taiwan
Restriction Fragment Length Polymorphisms
Single Nucleotide Polymorphism
DNA
High Pressure Liquid Chromatography
Confidence Intervals
Kidney
Polymerase Chain Reaction

Keywords

  • ADIPOQ
  • Arsenic
  • Obesity
  • Polymorphism
  • Renal Cell Carcinoma

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Adiponectin gene polymorphisms and obesity increase the susceptibility to arsenic-related renal cell carcinoma. / Hsueh, Yu Mei; Chen, Wei Jen; Lin, Ying Chin; Huang, Chao Yuan; Shiue, Horng Sheng; Yang, Shu Mei; Ao, Pui Lam; Pu, Yeong Shiau; Su, Chien Tien.

In: Toxicology and Applied Pharmacology, Vol. 350, 01.07.2018, p. 11-20.

Research output: Contribution to journalArticle

Hsueh, Yu Mei ; Chen, Wei Jen ; Lin, Ying Chin ; Huang, Chao Yuan ; Shiue, Horng Sheng ; Yang, Shu Mei ; Ao, Pui Lam ; Pu, Yeong Shiau ; Su, Chien Tien. / Adiponectin gene polymorphisms and obesity increase the susceptibility to arsenic-related renal cell carcinoma. In: Toxicology and Applied Pharmacology. 2018 ; Vol. 350. pp. 11-20.
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