Adipocyte IL-15 regulates local and systemic NK cell development

Yae Huei Liou, Szu Wen Wang, Chin Ling Chang, Po Lin Huang, Mau Sheng Hou, Yein Gei Lai, Gilbert Aaron Lee, Si Tse Jiang, Ching Yen Tsai, Nan Shih Liao

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

NK cell development and homeostasis require IL-15 produced by both hematopoietic and parenchymal cells. Certain hematopoietic IL-15 sources, such as macrophages and dendritic cells, are known, whereas the source of parenchymal IL-15 remains elusive. Using two types of adipocyte-specific Il15-/- mice, we identified adipocytes as a parenchymal IL-15 source that supported NK cell development nonredundantly. Both adipocyte-specific Il15-/- mice showed reduced IL-15 production specifically in the adipose tissue but impaired NK cell development in the spleen and liver in addition to the adipose tissue. We also found that the adipose tissue harbored NK progenitors as other niches (e.g. spleen) for NK cell development, and that NK cells derived from transplanted adipose tissue populated the recipient's spleen and liver. These findings suggest that adipocyte IL-15 contributes to systemic NK cell development by supporting NK cell development in the adipose tissue, which serves as a source of NK cells for other organs.

Original languageEnglish
Pages (from-to)1747-1758
Number of pages12
JournalJournal of Immunology
Volume193
Issue number4
DOIs
Publication statusPublished - Aug 15 2014

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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