Adherence to Statins Use and Risk of Dementia among Patients with Diabetes and Comorbid Hyperlipidemia

Ching Yuan Chang, Fang Ju Lin, Jin Liern Hong, Chung Hsuen Wu

Research output: Contribution to journalArticlepeer-review

Abstract

The results from previous observational studies and clinical trials about the neuroprotective benefits of statins use for the prevention of dementia are contradictory. It is unclear whether the neuroprotective benefits are experienced in a specific group with a higher risk of dementia, such as patients with concurrent diabetes and hyperlipidemia. We aimed to examine the association between adherence to statins and the risk of dementia among patients with diabetes and comorbid hyperlipidemia. This was a retrospective study with a new user design. We used data from the Taiwan National Health Insurance Research Database to identify patients with diabetes and comorbid hyperlipidemia. The occurrence of dementia was the study outcome. The adherence to statins was the exposure, which was measured by the proportion of days covered (PDC) of statins. The good adherence included patients with ≥80% PDC of statins. Cox proportional hazards regression models were used to evaluate the association between adherence to statins and dementia. Among 18,125 included individuals with diabetes and comorbid hyperlipidemia, 33.5% had good adherence to statins. Compared to poor adherence to statins, good adherence to statins was not significantly associated with a reduced risk of dementia (hazard ratio = 0.94; 95%confidence interval = 0.70-1.24) among patients with diabetes and comorbid hyperlipidemia. Good adherence to statins was not found to be associated with the risk of dementia among patients with diabetes and comorbid hyperlipidemia in Taiwan. Future studies with a more diverse study population are needed to evaluate the neuroprotective effects of statins use on dementia prevention.

Original languageEnglish
Pages (from-to)469580211019201
JournalInquiry : a journal of medical care organization, provision and financing
Volume58
DOIs
Publication statusPublished - Jan 1 2021

Keywords

  • adherence
  • dementia
  • diabetes
  • hyperlipidemia
  • statins

ASJC Scopus subject areas

  • Health Policy

Fingerprint Dive into the research topics of 'Adherence to Statins Use and Risk of Dementia among Patients with Diabetes and Comorbid Hyperlipidemia'. Together they form a unique fingerprint.

Cite this