Adenocarcinoma in the middle third of the stomach - An evaluation for the prognositc significance of clinicopathological features

Shyr Ming Sheen-Chen, Chih Wei Sheen, Fong Fu Chou, Mao Chan Chen, Feng Chi Chen, Yaw Sen Chen, Jyh Jou Chen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background/Aims: The prognosis of patients with gastric adenocarcinoma varies with the location of the tumor. Adenocarcinoma in the middle third of the stomach has been claimed to have a better outcome than those in other locations. However, there is still very limited information specifically regarding the prognostic factors which influence the survival time of patients with adenocarcinoma in the middle third of the stomach. This retrospective study was designed with the aim to evaluate and uncover the possible significant clinicopathological parameters for adenocarcinoma in the middle third of the stomach. Methodology: Between 1986 and 1992, 363 patients underwent gastric resection for primary gastric adenocarcinoma at this hospital. Fifty-two (14.3%) of these patients were included in this study and they all met the following criteria: 1) tumor primarily located in the middle third of the stomach without distant metastases or peritoneal seeding, 2) undergoing curative resection and 3) undergoing R2 nodal dissection, at least. The clinicopathological findings were obtained by detailed review of the medical records and the histologic slides. All surviving patients were also contacted and their current conditions were recorded. Results: The overall 5-year survival rate (Kaplan-Meier method) was 42.5%. In univariate survival analysis by Kaplan-Meier method and long-rank test, serosal invasion (p < 0.01), lymph node metastasis (p < 0.01) and lymphatic involvement (p < 0.01) had an individual prognostic significance. When a multivariate analysis using Cox proportional hazards regression was performed, serosal invasion (P < 0.01) and lymphatic involvement (p < 0.05) appeared as the only true independent prognostic factors regarding long-term survival. When these 52 patients were categorized into patients with early gastric cancer (n = 10) and patients with advanced gastric cancer (n = 42), there was a significant difference (p < 0.01) between the survival rates (90.0% vs. 29.1 %). When these tumors were further categorized into early gastric cancer (n = 10), early simulating advanced gastric cancer (n = 14) and Borrmann type advanced gastric cancer (n = 28), there were significant differences (P < 0.01 and P < 0.01, respectively) in 5-year overall survival rates between early gastric cancer (90.0%) and Borrmann type advanced gastric cancer ( 18.9%), also between early simulating advanced gastric cancer (52.5%) and Borrmann type advanced gastric cancer (18.9%). UICC stage also had significant influence (P < 0.01) on the survival rates. Conclusions: Seroscal invasion and lymphatic involvement are the significant, indepenent prognostic factors in predicting the survival rate of patients with adenocarcinoma in the middle third of the stomach. Since more advanced stage tumors usually carry a poorer prognosis, early detection is of extreme importance for improving the survival rate.

Original languageEnglish
Pages (from-to)1488-1494
Number of pages7
JournalHepato-Gastroenterology
Volume44
Issue number17
Publication statusPublished - Oct 30 1997
Externally publishedYes

Fingerprint

Stomach Neoplasms
Stomach
Adenocarcinoma
Survival Rate
Neoplasms
Neoplasm Metastasis
Survival
Survival Analysis
Medical Records
Dissection
Multivariate Analysis
Retrospective Studies
Lymph Nodes

Keywords

  • Adenocarcinoma of the stomach
  • Advanced gastric cancer
  • Early gastric cancer

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Sheen-Chen, S. M., Sheen, C. W., Chou, F. F., Chen, M. C., Chen, F. C., Chen, Y. S., & Chen, J. J. (1997). Adenocarcinoma in the middle third of the stomach - An evaluation for the prognositc significance of clinicopathological features. Hepato-Gastroenterology, 44(17), 1488-1494.

Adenocarcinoma in the middle third of the stomach - An evaluation for the prognositc significance of clinicopathological features. / Sheen-Chen, Shyr Ming; Sheen, Chih Wei; Chou, Fong Fu; Chen, Mao Chan; Chen, Feng Chi; Chen, Yaw Sen; Chen, Jyh Jou.

In: Hepato-Gastroenterology, Vol. 44, No. 17, 30.10.1997, p. 1488-1494.

Research output: Contribution to journalArticle

Sheen-Chen, Shyr Ming ; Sheen, Chih Wei ; Chou, Fong Fu ; Chen, Mao Chan ; Chen, Feng Chi ; Chen, Yaw Sen ; Chen, Jyh Jou. / Adenocarcinoma in the middle third of the stomach - An evaluation for the prognositc significance of clinicopathological features. In: Hepato-Gastroenterology. 1997 ; Vol. 44, No. 17. pp. 1488-1494.
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abstract = "Background/Aims: The prognosis of patients with gastric adenocarcinoma varies with the location of the tumor. Adenocarcinoma in the middle third of the stomach has been claimed to have a better outcome than those in other locations. However, there is still very limited information specifically regarding the prognostic factors which influence the survival time of patients with adenocarcinoma in the middle third of the stomach. This retrospective study was designed with the aim to evaluate and uncover the possible significant clinicopathological parameters for adenocarcinoma in the middle third of the stomach. Methodology: Between 1986 and 1992, 363 patients underwent gastric resection for primary gastric adenocarcinoma at this hospital. Fifty-two (14.3{\%}) of these patients were included in this study and they all met the following criteria: 1) tumor primarily located in the middle third of the stomach without distant metastases or peritoneal seeding, 2) undergoing curative resection and 3) undergoing R2 nodal dissection, at least. The clinicopathological findings were obtained by detailed review of the medical records and the histologic slides. All surviving patients were also contacted and their current conditions were recorded. Results: The overall 5-year survival rate (Kaplan-Meier method) was 42.5{\%}. In univariate survival analysis by Kaplan-Meier method and long-rank test, serosal invasion (p < 0.01), lymph node metastasis (p < 0.01) and lymphatic involvement (p < 0.01) had an individual prognostic significance. When a multivariate analysis using Cox proportional hazards regression was performed, serosal invasion (P < 0.01) and lymphatic involvement (p < 0.05) appeared as the only true independent prognostic factors regarding long-term survival. When these 52 patients were categorized into patients with early gastric cancer (n = 10) and patients with advanced gastric cancer (n = 42), there was a significant difference (p < 0.01) between the survival rates (90.0{\%} vs. 29.1 {\%}). When these tumors were further categorized into early gastric cancer (n = 10), early simulating advanced gastric cancer (n = 14) and Borrmann type advanced gastric cancer (n = 28), there were significant differences (P < 0.01 and P < 0.01, respectively) in 5-year overall survival rates between early gastric cancer (90.0{\%}) and Borrmann type advanced gastric cancer ( 18.9{\%}), also between early simulating advanced gastric cancer (52.5{\%}) and Borrmann type advanced gastric cancer (18.9{\%}). UICC stage also had significant influence (P < 0.01) on the survival rates. Conclusions: Seroscal invasion and lymphatic involvement are the significant, indepenent prognostic factors in predicting the survival rate of patients with adenocarcinoma in the middle third of the stomach. Since more advanced stage tumors usually carry a poorer prognosis, early detection is of extreme importance for improving the survival rate.",
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AU - Chen, Yaw Sen

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