Addressing stem cell therapeutic approaches in pathobiology of diabetes and its complications

Bou Yue Peng, Navneet Kumar Dubey, Viraj Krishna Mishra, Feng Chou Tsai, Rajni Dubey, Win Ping Deng, Hong Jian Wei

Research output: Contribution to journalArticle

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Abstract

High morbidity and mortality of diabetes mellitus (DM) throughout the human population is a serious threat which needs to be addressed cautiously. Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are most prevalent forms. Disruption in insulin regulation and resistance leads to increased formation and accumulation of advanced end products (AGEs), which further enhance oxidative and nitrosative stress leading to microvascular (retinopathy, neuropathy, and nephropathy) and macrovascular complications. These complications affect the normal function of organ and tissues and may cause life-threatening disorders, if hyperglycemia persists and improperly controlled. Current and traditional treatment procedures are only focused on to regulate the insulin level and do not cure the diabetic complications. Pancreatic transplantation seemed a viable alternative; however, it is limited due to lack of donors. Cell-based therapy such as stem cells is considered as a promising therapeutic agent against DM and diabetic complications owing to their multilineage differentiation and regeneration potential. Previous studies have demonstrated the various impacts of both pluripotent and multipotent stem cells on DM and its micro- and macrovascular complications. Therefore, this review summarizes the potential of stem cells to treat DM and its related complications.

LanguageEnglish
Article number7806435
JournalJournal of Diabetes Research
Volume2018
DOIs
Publication statusPublished - Jan 1 2018

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Diabetes Complications
Diabetes Mellitus
Stem Cells
Multipotent Stem Cells
Pluripotent Stem Cells
Therapeutics
Cell- and Tissue-Based Therapy
Type 1 Diabetes Mellitus
Hyperglycemia
Type 2 Diabetes Mellitus
Insulin Resistance
Regeneration
Oxidative Stress
Transplantation
Insulin
Morbidity
Mortality
Population

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Addressing stem cell therapeutic approaches in pathobiology of diabetes and its complications. / Peng, Bou Yue; Dubey, Navneet Kumar; Mishra, Viraj Krishna; Tsai, Feng Chou; Dubey, Rajni; Deng, Win Ping; Wei, Hong Jian.

In: Journal of Diabetes Research, Vol. 2018, 7806435, 01.01.2018.

Research output: Contribution to journalArticle

Peng, Bou Yue ; Dubey, Navneet Kumar ; Mishra, Viraj Krishna ; Tsai, Feng Chou ; Dubey, Rajni ; Deng, Win Ping ; Wei, Hong Jian. / Addressing stem cell therapeutic approaches in pathobiology of diabetes and its complications. In: Journal of Diabetes Research. 2018 ; Vol. 2018.
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