Added Value of Computed Tomography Virtual Intravascular Endoscopy in the Evaluation of Coronary Arteries with Stents or Plaques

Patricia Wanping Wu, Pei Kwei Tsay, Zhonghua Sun, Syu Jyun Peng, Chia Yen Lee, Ming Yi Hsu, Yu Shien Ko, I. Chang Hsieh, Ming Shien Wen, Yung Liang Wan

Research output: Contribution to journalArticlepeer-review

Abstract

Coronary computed tomography angiography (CCTA) is a widely used imaging modality for diagnosing coronary artery disease (CAD) but is limited by a high false positive rate when evaluating coronary arteries with stents and heavy calcifications. Virtual intravascular endoscopy (VIE) images generated from CCTA can be used to qualitatively assess the vascular lumen and might be helpful for overcoming this challenge. In this study, one hundred subjects with coronary stents underwent both CCTA and invasive coronary angiography (ICA). A total of 902 vessel segments were analyzed using CCTA and VIE. The vessel segments were first analyzed on CCTA alone. Then, using VIE, the segments were classified qualitatively as either negative or positive for in-stent reste-nosis (ISR) or CAD. These results were compared, using ICA as the reference, to determine the added diagnostic value of VIE. Of the 902 analyzed vessel segments, CCTA/VIE had sensitivity, specificity, accuracy, positive predictive value, and negative predictive value (shown in %) of 93.9/90.2, 96.2/98.2, 96.0/97.7, 70.0/83.1, and 99.4/99.0, respectively, in diagnosing ISR or CAD, with significantly improved specificity (p = 0.025), accuracy (p = 0.046), and positive predictive value (p = 0.047). VIE can be a helpful addition to CCTA when evaluating coronary arteries.

Original languageEnglish
Article number390
JournalDiagnostics
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 2022

Keywords

  • Coronary artery disease (CAD)
  • Coronary calcification
  • Coronary computed tomography angiography (CCTA)
  • Coronary stent
  • Virtual intravascular endoscopy (VIE)

ASJC Scopus subject areas

  • Clinical Biochemistry

Fingerprint

Dive into the research topics of 'Added Value of Computed Tomography Virtual Intravascular Endoscopy in the Evaluation of Coronary Arteries with Stents or Plaques'. Together they form a unique fingerprint.

Cite this