Acyltransferases for secreted signalling proteins (Review)

Shu Chun Chang, Anthony I. Magee

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Members of the MBOAT family of multispanning transmembrane enzymes catalyze the acylation of important secreted signalling proteins of the Hedgehog, Wg/Wnt and ghrelin families. Acylation of these substrates occurs during transport through the secretory pathway and plays key roles in their biological activity and spread from producing cells, contributing to the formation of appropriate extracellular concentration gradients. Characterization of these enzymes could lead to their identification as therapeutic targets for diverse human diseases such as cancers, obesity and diabetes.

Original languageEnglish
Pages (from-to)104-113
Number of pages10
JournalMolecular Membrane Biology
Volume26
Issue number1-2
DOIs
Publication statusPublished - Jan 2009
Externally publishedYes

Fingerprint

Acyltransferases
Acylation
Hedgehog Proteins
Ghrelin
Secretory Pathway
Enzymes
Proteins
Obesity
Neoplasms
Therapeutics

Keywords

  • Acylation
  • Ghrelin
  • Hedgehog
  • MBOAT
  • Palmitoylation
  • Protein acyl transferase
  • Wingless/Wnt

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Acyltransferases for secreted signalling proteins (Review). / Chang, Shu Chun; Magee, Anthony I.

In: Molecular Membrane Biology, Vol. 26, No. 1-2, 01.2009, p. 104-113.

Research output: Contribution to journalReview article

Chang, Shu Chun ; Magee, Anthony I. / Acyltransferases for secreted signalling proteins (Review). In: Molecular Membrane Biology. 2009 ; Vol. 26, No. 1-2. pp. 104-113.
@article{c56203fe1b9f41dca9dc8ae0b56be1a7,
title = "Acyltransferases for secreted signalling proteins (Review)",
abstract = "Members of the MBOAT family of multispanning transmembrane enzymes catalyze the acylation of important secreted signalling proteins of the Hedgehog, Wg/Wnt and ghrelin families. Acylation of these substrates occurs during transport through the secretory pathway and plays key roles in their biological activity and spread from producing cells, contributing to the formation of appropriate extracellular concentration gradients. Characterization of these enzymes could lead to their identification as therapeutic targets for diverse human diseases such as cancers, obesity and diabetes.",
keywords = "Acylation, Ghrelin, Hedgehog, MBOAT, Palmitoylation, Protein acyl transferase, Wingless/Wnt",
author = "Chang, {Shu Chun} and Magee, {Anthony I.}",
year = "2009",
month = "1",
doi = "10.1080/09687680802706432",
language = "English",
volume = "26",
pages = "104--113",
journal = "Molecular Membrane Biology",
issn = "0968-7688",
publisher = "Informa Healthcare",
number = "1-2",

}

TY - JOUR

T1 - Acyltransferases for secreted signalling proteins (Review)

AU - Chang, Shu Chun

AU - Magee, Anthony I.

PY - 2009/1

Y1 - 2009/1

N2 - Members of the MBOAT family of multispanning transmembrane enzymes catalyze the acylation of important secreted signalling proteins of the Hedgehog, Wg/Wnt and ghrelin families. Acylation of these substrates occurs during transport through the secretory pathway and plays key roles in their biological activity and spread from producing cells, contributing to the formation of appropriate extracellular concentration gradients. Characterization of these enzymes could lead to their identification as therapeutic targets for diverse human diseases such as cancers, obesity and diabetes.

AB - Members of the MBOAT family of multispanning transmembrane enzymes catalyze the acylation of important secreted signalling proteins of the Hedgehog, Wg/Wnt and ghrelin families. Acylation of these substrates occurs during transport through the secretory pathway and plays key roles in their biological activity and spread from producing cells, contributing to the formation of appropriate extracellular concentration gradients. Characterization of these enzymes could lead to their identification as therapeutic targets for diverse human diseases such as cancers, obesity and diabetes.

KW - Acylation

KW - Ghrelin

KW - Hedgehog

KW - MBOAT

KW - Palmitoylation

KW - Protein acyl transferase

KW - Wingless/Wnt

UR - http://www.scopus.com/inward/record.url?scp=61449211070&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61449211070&partnerID=8YFLogxK

U2 - 10.1080/09687680802706432

DO - 10.1080/09687680802706432

M3 - Review article

VL - 26

SP - 104

EP - 113

JO - Molecular Membrane Biology

JF - Molecular Membrane Biology

SN - 0968-7688

IS - 1-2

ER -