Acyltransferases for secreted signalling proteins (Review)

Shu Chun Chang, Anthony I. Magee

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Members of the MBOAT family of multispanning transmembrane enzymes catalyze the acylation of important secreted signalling proteins of the Hedgehog, Wg/Wnt and ghrelin families. Acylation of these substrates occurs during transport through the secretory pathway and plays key roles in their biological activity and spread from producing cells, contributing to the formation of appropriate extracellular concentration gradients. Characterization of these enzymes could lead to their identification as therapeutic targets for diverse human diseases such as cancers, obesity and diabetes.

Original languageEnglish
Pages (from-to)104-113
Number of pages10
JournalMolecular Membrane Biology
Volume26
Issue number1-2
DOIs
Publication statusPublished - Jan 2009
Externally publishedYes

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Keywords

  • Acylation
  • Ghrelin
  • Hedgehog
  • MBOAT
  • Palmitoylation
  • Protein acyl transferase
  • Wingless/Wnt

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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