Acute ST-elevation myocardial infarction in young patients

15 Years of experience in a single center

Su Kiat Chua, Huei Fong Hung, Kou Gi Shyu, Jun Jack Cheng, Ng Zuan Chiu, Che Ming Chang, Sheng Chang Lin, Jer Young Liou, Huey Ming Lo, Peiliang Kuan, Shih Huang Lee

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: There have been few studies done regarding young patients with ST-elevation myocardial infarction (STEMI). The purpose of this study was to investigate the clinical characteristics and coronary angiographic features in young patientswith STEMI. Methods: We collected data on 849 consecutive patients with STEMI from 1992 to 2006. Baseline clinical characteristics, coronary anatomy, and outcome were compared in young (≤45 yrs) and older patients (>45 yrs). Results: Young patients presented 11.6% of all patients with STEMI. These patients were predominantly male (92.9% vs 80.3%, P <0.001), more likely to smoke (75.8% vs 47.2%, P <0.001), obese (48.2% vs 27.9%, P = 0.002), have higher triglyceride levels (176.9± 153.8 mg/dL vs 140.7± 112.7mg/dL, P = 0.005), and lower high-density lipoprotein cholesterol (37.1 ± 7.9mg/dL vs 42.8 ± 14.3mg/dL, P = 0.005) than older patients. Also, younger patients had a shorter hospital stay (7.1 ± 4.9 d vs 8.5 ± 6.7 d, P = 0.04), less in-hospital morbidity (29.3% vs 39.7%, P = 0.02), and mortality (3.0% vs 12.3%, P = 0.002). Killip class III or IV could predict in-hospital morbidity and mortality in young patients. Both groups had similar rates of repeated percutaneous coronary intervention (PCI; 45.5% vs 41.5%, P = 0.23) and reinfarction (6.1% vs 3.2%, P = 0.32). Mortality rate during follow-up was significantly lower in younger patients (3.0% vs 19.6%, P <0.001). Conclusion: Cigarette smoking, obesity, and dyslipidemia were the most important modifiable risk factors in young patients with STEMI. These patients had a better outcome than older patients without differences in repeated PCI and reinfarction between them. Only Killip class III or IV could predict in-hospitalmorbidity and mortality in young patients with STEMI.

Original languageEnglish
Pages (from-to)140-148
Number of pages9
JournalClinical Cardiology
Volume33
Issue number3
DOIs
Publication statusPublished - Mar 2010

Fingerprint

ST Elevation Myocardial Infarction
Mortality
Morbidity
Percutaneous Coronary Intervention
Dyslipidemias
Hospital Mortality
Smoke
HDL Cholesterol
Length of Stay
Anatomy
Triglycerides
Obesity
Smoking

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Chua, S. K., Hung, H. F., Shyu, K. G., Cheng, J. J., Chiu, N. Z., Chang, C. M., ... Lee, S. H. (2010). Acute ST-elevation myocardial infarction in young patients: 15 Years of experience in a single center. Clinical Cardiology, 33(3), 140-148. https://doi.org/10.1002/clc.20718

Acute ST-elevation myocardial infarction in young patients : 15 Years of experience in a single center. / Chua, Su Kiat; Hung, Huei Fong; Shyu, Kou Gi; Cheng, Jun Jack; Chiu, Ng Zuan; Chang, Che Ming; Lin, Sheng Chang; Liou, Jer Young; Lo, Huey Ming; Kuan, Peiliang; Lee, Shih Huang.

In: Clinical Cardiology, Vol. 33, No. 3, 03.2010, p. 140-148.

Research output: Contribution to journalArticle

Chua, SK, Hung, HF, Shyu, KG, Cheng, JJ, Chiu, NZ, Chang, CM, Lin, SC, Liou, JY, Lo, HM, Kuan, P & Lee, SH 2010, 'Acute ST-elevation myocardial infarction in young patients: 15 Years of experience in a single center', Clinical Cardiology, vol. 33, no. 3, pp. 140-148. https://doi.org/10.1002/clc.20718
Chua, Su Kiat ; Hung, Huei Fong ; Shyu, Kou Gi ; Cheng, Jun Jack ; Chiu, Ng Zuan ; Chang, Che Ming ; Lin, Sheng Chang ; Liou, Jer Young ; Lo, Huey Ming ; Kuan, Peiliang ; Lee, Shih Huang. / Acute ST-elevation myocardial infarction in young patients : 15 Years of experience in a single center. In: Clinical Cardiology. 2010 ; Vol. 33, No. 3. pp. 140-148.
@article{fc476168cc1e418394da498299e5963b,
title = "Acute ST-elevation myocardial infarction in young patients: 15 Years of experience in a single center",
abstract = "Background: There have been few studies done regarding young patients with ST-elevation myocardial infarction (STEMI). The purpose of this study was to investigate the clinical characteristics and coronary angiographic features in young patientswith STEMI. Methods: We collected data on 849 consecutive patients with STEMI from 1992 to 2006. Baseline clinical characteristics, coronary anatomy, and outcome were compared in young (≤45 yrs) and older patients (>45 yrs). Results: Young patients presented 11.6{\%} of all patients with STEMI. These patients were predominantly male (92.9{\%} vs 80.3{\%}, P <0.001), more likely to smoke (75.8{\%} vs 47.2{\%}, P <0.001), obese (48.2{\%} vs 27.9{\%}, P = 0.002), have higher triglyceride levels (176.9± 153.8 mg/dL vs 140.7± 112.7mg/dL, P = 0.005), and lower high-density lipoprotein cholesterol (37.1 ± 7.9mg/dL vs 42.8 ± 14.3mg/dL, P = 0.005) than older patients. Also, younger patients had a shorter hospital stay (7.1 ± 4.9 d vs 8.5 ± 6.7 d, P = 0.04), less in-hospital morbidity (29.3{\%} vs 39.7{\%}, P = 0.02), and mortality (3.0{\%} vs 12.3{\%}, P = 0.002). Killip class III or IV could predict in-hospital morbidity and mortality in young patients. Both groups had similar rates of repeated percutaneous coronary intervention (PCI; 45.5{\%} vs 41.5{\%}, P = 0.23) and reinfarction (6.1{\%} vs 3.2{\%}, P = 0.32). Mortality rate during follow-up was significantly lower in younger patients (3.0{\%} vs 19.6{\%}, P <0.001). Conclusion: Cigarette smoking, obesity, and dyslipidemia were the most important modifiable risk factors in young patients with STEMI. These patients had a better outcome than older patients without differences in repeated PCI and reinfarction between them. Only Killip class III or IV could predict in-hospitalmorbidity and mortality in young patients with STEMI.",
author = "Chua, {Su Kiat} and Hung, {Huei Fong} and Shyu, {Kou Gi} and Cheng, {Jun Jack} and Chiu, {Ng Zuan} and Chang, {Che Ming} and Lin, {Sheng Chang} and Liou, {Jer Young} and Lo, {Huey Ming} and Peiliang Kuan and Lee, {Shih Huang}",
year = "2010",
month = "3",
doi = "10.1002/clc.20718",
language = "English",
volume = "33",
pages = "140--148",
journal = "Clinical Cardiology",
issn = "0160-9289",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Acute ST-elevation myocardial infarction in young patients

T2 - 15 Years of experience in a single center

AU - Chua, Su Kiat

AU - Hung, Huei Fong

AU - Shyu, Kou Gi

AU - Cheng, Jun Jack

AU - Chiu, Ng Zuan

AU - Chang, Che Ming

AU - Lin, Sheng Chang

AU - Liou, Jer Young

AU - Lo, Huey Ming

AU - Kuan, Peiliang

AU - Lee, Shih Huang

PY - 2010/3

Y1 - 2010/3

N2 - Background: There have been few studies done regarding young patients with ST-elevation myocardial infarction (STEMI). The purpose of this study was to investigate the clinical characteristics and coronary angiographic features in young patientswith STEMI. Methods: We collected data on 849 consecutive patients with STEMI from 1992 to 2006. Baseline clinical characteristics, coronary anatomy, and outcome were compared in young (≤45 yrs) and older patients (>45 yrs). Results: Young patients presented 11.6% of all patients with STEMI. These patients were predominantly male (92.9% vs 80.3%, P <0.001), more likely to smoke (75.8% vs 47.2%, P <0.001), obese (48.2% vs 27.9%, P = 0.002), have higher triglyceride levels (176.9± 153.8 mg/dL vs 140.7± 112.7mg/dL, P = 0.005), and lower high-density lipoprotein cholesterol (37.1 ± 7.9mg/dL vs 42.8 ± 14.3mg/dL, P = 0.005) than older patients. Also, younger patients had a shorter hospital stay (7.1 ± 4.9 d vs 8.5 ± 6.7 d, P = 0.04), less in-hospital morbidity (29.3% vs 39.7%, P = 0.02), and mortality (3.0% vs 12.3%, P = 0.002). Killip class III or IV could predict in-hospital morbidity and mortality in young patients. Both groups had similar rates of repeated percutaneous coronary intervention (PCI; 45.5% vs 41.5%, P = 0.23) and reinfarction (6.1% vs 3.2%, P = 0.32). Mortality rate during follow-up was significantly lower in younger patients (3.0% vs 19.6%, P <0.001). Conclusion: Cigarette smoking, obesity, and dyslipidemia were the most important modifiable risk factors in young patients with STEMI. These patients had a better outcome than older patients without differences in repeated PCI and reinfarction between them. Only Killip class III or IV could predict in-hospitalmorbidity and mortality in young patients with STEMI.

AB - Background: There have been few studies done regarding young patients with ST-elevation myocardial infarction (STEMI). The purpose of this study was to investigate the clinical characteristics and coronary angiographic features in young patientswith STEMI. Methods: We collected data on 849 consecutive patients with STEMI from 1992 to 2006. Baseline clinical characteristics, coronary anatomy, and outcome were compared in young (≤45 yrs) and older patients (>45 yrs). Results: Young patients presented 11.6% of all patients with STEMI. These patients were predominantly male (92.9% vs 80.3%, P <0.001), more likely to smoke (75.8% vs 47.2%, P <0.001), obese (48.2% vs 27.9%, P = 0.002), have higher triglyceride levels (176.9± 153.8 mg/dL vs 140.7± 112.7mg/dL, P = 0.005), and lower high-density lipoprotein cholesterol (37.1 ± 7.9mg/dL vs 42.8 ± 14.3mg/dL, P = 0.005) than older patients. Also, younger patients had a shorter hospital stay (7.1 ± 4.9 d vs 8.5 ± 6.7 d, P = 0.04), less in-hospital morbidity (29.3% vs 39.7%, P = 0.02), and mortality (3.0% vs 12.3%, P = 0.002). Killip class III or IV could predict in-hospital morbidity and mortality in young patients. Both groups had similar rates of repeated percutaneous coronary intervention (PCI; 45.5% vs 41.5%, P = 0.23) and reinfarction (6.1% vs 3.2%, P = 0.32). Mortality rate during follow-up was significantly lower in younger patients (3.0% vs 19.6%, P <0.001). Conclusion: Cigarette smoking, obesity, and dyslipidemia were the most important modifiable risk factors in young patients with STEMI. These patients had a better outcome than older patients without differences in repeated PCI and reinfarction between them. Only Killip class III or IV could predict in-hospitalmorbidity and mortality in young patients with STEMI.

UR - http://www.scopus.com/inward/record.url?scp=77949681535&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949681535&partnerID=8YFLogxK

U2 - 10.1002/clc.20718

DO - 10.1002/clc.20718

M3 - Article

VL - 33

SP - 140

EP - 148

JO - Clinical Cardiology

JF - Clinical Cardiology

SN - 0160-9289

IS - 3

ER -