Acute respiratory distress syndrome following intrathecal methotrexate administration: A case report and review of literature

M. S. Dai, C. L. Ho, Y. C. Chen, W. Y. Kao, T. Y. Chao

Research output: Contribution to journalArticle

16 Citations (Scopus)


Acute Respiratory distress syndrome (ARDS) is a rare complication following intrathecal (IT) injection of methotrexate (MTX) in adult acute lymphoblastic leukemia (ALL) patients. A 19-year-old man with ALL developed strikingly acute respiratory failure during central nervous system (CNS) prophylaxis with IT MTX administration and cranial irradiation. Histopathologic study of the lungs revealed a pattern of diffuse alveolar damage with interstitial cellular infiltration. His symptoms were relieved soon following treatment with corticosteroids and the pulmonary infiltrates resolved gradually. Pulmonary symptoms did not recur as he was continuously treated with oral corticosteroids.

Original languageEnglish
Pages (from-to)696-699
Number of pages4
JournalAnnals of Hematology
Issue number12
Publication statusPublished - 2000
Externally publishedYes



  • Acute respiratory distress syndrome
  • Intrathecal
  • Methotrexate

ASJC Scopus subject areas

  • Hematology

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