Acute metaldehyde poisoning in Taiwan

Chi Chung Shih, Shy Shin Chang, Yi Ling Chan, Jih Chang Chen, Meng Wei Chang, Meng Sheng Tung, Jou Fang Deng, Chen Chang Yang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Metaldehyde, a cyclic tetramer of acetaldehyde, is a widely used molluscicide. Although cases with acute metaldehyde poisoning have been reported, the occurrence of severe poisoning is uncommon. To provide more information on human metaldehyde poisoning, we reviewed 15 cases of metaldehyde exposure reported to the Taiwan National Poison Control Center at the Taipei Veterans General Hospital between 1991 and 2002. While 7 patients were asymptomatic, the other 8 patients, including 4 who coingested alcohol or other poisons, exhibited toxic manifestations of abdominal pain, dizziness, nausea, irritation of oral mucosa, and seizures after oral exposure. One patient died after ingesting 12 g (or 258.6 mg/kg) of metaldehyde. Although the toxicity from metaldehyde is largely mild, the clinical course of metaldehyde poisoning may be rapidly deteriorating and fatal on rare occasions. Physicians should therefore be cautious in managing patients with metaldehyde poisoning, and vigorous supportive measures should be promptly instituted in patients who manifest severe toxicity.

Original languageEnglish
Pages (from-to)140-143
Number of pages4
JournalVeterinary and Human Toxicology
Volume46
Issue number3
Publication statusPublished - Jun 1 2004
Externally publishedYes

Fingerprint

metaldehyde
Taiwan
Poisoning
poisoning
Poisons
Toxicity
digestive tract mucosa
Poison Control Centers
molluscicides
veterans
toxicity
Veterans Hospitals
nausea
Acetaldehyde
acetaldehyde
Mouth Mucosa
Dizziness
seizures
physicians
disease course

ASJC Scopus subject areas

  • Toxicology
  • veterinary(all)
  • Health, Toxicology and Mutagenesis

Cite this

Shih, C. C., Chang, S. S., Chan, Y. L., Chen, J. C., Chang, M. W., Tung, M. S., ... Yang, C. C. (2004). Acute metaldehyde poisoning in Taiwan. Veterinary and Human Toxicology, 46(3), 140-143.

Acute metaldehyde poisoning in Taiwan. / Shih, Chi Chung; Chang, Shy Shin; Chan, Yi Ling; Chen, Jih Chang; Chang, Meng Wei; Tung, Meng Sheng; Deng, Jou Fang; Yang, Chen Chang.

In: Veterinary and Human Toxicology, Vol. 46, No. 3, 01.06.2004, p. 140-143.

Research output: Contribution to journalArticle

Shih, CC, Chang, SS, Chan, YL, Chen, JC, Chang, MW, Tung, MS, Deng, JF & Yang, CC 2004, 'Acute metaldehyde poisoning in Taiwan', Veterinary and Human Toxicology, vol. 46, no. 3, pp. 140-143.
Shih CC, Chang SS, Chan YL, Chen JC, Chang MW, Tung MS et al. Acute metaldehyde poisoning in Taiwan. Veterinary and Human Toxicology. 2004 Jun 1;46(3):140-143.
Shih, Chi Chung ; Chang, Shy Shin ; Chan, Yi Ling ; Chen, Jih Chang ; Chang, Meng Wei ; Tung, Meng Sheng ; Deng, Jou Fang ; Yang, Chen Chang. / Acute metaldehyde poisoning in Taiwan. In: Veterinary and Human Toxicology. 2004 ; Vol. 46, No. 3. pp. 140-143.
@article{292f7d43c76b4c50a1fe9f8e2d52d183,
title = "Acute metaldehyde poisoning in Taiwan",
abstract = "Metaldehyde, a cyclic tetramer of acetaldehyde, is a widely used molluscicide. Although cases with acute metaldehyde poisoning have been reported, the occurrence of severe poisoning is uncommon. To provide more information on human metaldehyde poisoning, we reviewed 15 cases of metaldehyde exposure reported to the Taiwan National Poison Control Center at the Taipei Veterans General Hospital between 1991 and 2002. While 7 patients were asymptomatic, the other 8 patients, including 4 who coingested alcohol or other poisons, exhibited toxic manifestations of abdominal pain, dizziness, nausea, irritation of oral mucosa, and seizures after oral exposure. One patient died after ingesting 12 g (or 258.6 mg/kg) of metaldehyde. Although the toxicity from metaldehyde is largely mild, the clinical course of metaldehyde poisoning may be rapidly deteriorating and fatal on rare occasions. Physicians should therefore be cautious in managing patients with metaldehyde poisoning, and vigorous supportive measures should be promptly instituted in patients who manifest severe toxicity.",
author = "Shih, {Chi Chung} and Chang, {Shy Shin} and Chan, {Yi Ling} and Chen, {Jih Chang} and Chang, {Meng Wei} and Tung, {Meng Sheng} and Deng, {Jou Fang} and Yang, {Chen Chang}",
year = "2004",
month = "6",
day = "1",
language = "English",
volume = "46",
pages = "140--143",
journal = "Veterinary and Human Toxicology",
issn = "0145-6296",
publisher = "Comparative Toxicology Laboratories",
number = "3",

}

TY - JOUR

T1 - Acute metaldehyde poisoning in Taiwan

AU - Shih, Chi Chung

AU - Chang, Shy Shin

AU - Chan, Yi Ling

AU - Chen, Jih Chang

AU - Chang, Meng Wei

AU - Tung, Meng Sheng

AU - Deng, Jou Fang

AU - Yang, Chen Chang

PY - 2004/6/1

Y1 - 2004/6/1

N2 - Metaldehyde, a cyclic tetramer of acetaldehyde, is a widely used molluscicide. Although cases with acute metaldehyde poisoning have been reported, the occurrence of severe poisoning is uncommon. To provide more information on human metaldehyde poisoning, we reviewed 15 cases of metaldehyde exposure reported to the Taiwan National Poison Control Center at the Taipei Veterans General Hospital between 1991 and 2002. While 7 patients were asymptomatic, the other 8 patients, including 4 who coingested alcohol or other poisons, exhibited toxic manifestations of abdominal pain, dizziness, nausea, irritation of oral mucosa, and seizures after oral exposure. One patient died after ingesting 12 g (or 258.6 mg/kg) of metaldehyde. Although the toxicity from metaldehyde is largely mild, the clinical course of metaldehyde poisoning may be rapidly deteriorating and fatal on rare occasions. Physicians should therefore be cautious in managing patients with metaldehyde poisoning, and vigorous supportive measures should be promptly instituted in patients who manifest severe toxicity.

AB - Metaldehyde, a cyclic tetramer of acetaldehyde, is a widely used molluscicide. Although cases with acute metaldehyde poisoning have been reported, the occurrence of severe poisoning is uncommon. To provide more information on human metaldehyde poisoning, we reviewed 15 cases of metaldehyde exposure reported to the Taiwan National Poison Control Center at the Taipei Veterans General Hospital between 1991 and 2002. While 7 patients were asymptomatic, the other 8 patients, including 4 who coingested alcohol or other poisons, exhibited toxic manifestations of abdominal pain, dizziness, nausea, irritation of oral mucosa, and seizures after oral exposure. One patient died after ingesting 12 g (or 258.6 mg/kg) of metaldehyde. Although the toxicity from metaldehyde is largely mild, the clinical course of metaldehyde poisoning may be rapidly deteriorating and fatal on rare occasions. Physicians should therefore be cautious in managing patients with metaldehyde poisoning, and vigorous supportive measures should be promptly instituted in patients who manifest severe toxicity.

UR - http://www.scopus.com/inward/record.url?scp=2442553761&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442553761&partnerID=8YFLogxK

M3 - Article

C2 - 15171491

AN - SCOPUS:2442553761

VL - 46

SP - 140

EP - 143

JO - Veterinary and Human Toxicology

JF - Veterinary and Human Toxicology

SN - 0145-6296

IS - 3

ER -