Acute kidney injury and the potential for ATF3-regulated epigenetic therapy

Ching Feng Cheng, Heng Lin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The incidence of mortality in acute renal failure (ARF) induced by ischemia-reperfusion (I/R) injury or septic shock is high. Previous studies using animal models of ARF reported that inflammation-induced macrophage recruitment in endothelial cells, along with I/R-induced production of inflammatory cytokines and chemokines in tubule epithelial cells, results in macrophage and neutrophil accumulation, and that both ultimately lead to irreversible kidney injury. Recent studies suggest that ARF may also induce a beneficial stress response program and express many transcriptional regulators, including activating transcription factor 3 (ATF3). ATF3 is a member of the ATF/CREB subfamily of the basic-region leucine zipper (bZIP) family. Recent research has shed new light on the protective role of the ATF3 signaling pathway in attenuating inflammation and I/R-induced tubular cell death and nephrotoxicity. A recent clinical study also reported that ATF3 can serve as an indicator of acute kidney injury (AKI). AKI is associated with a robust inflammatory effect with increased levels of cytokines, including IL-6, IL-12, and IFNγ. By inhibiting these cytokines, the ATF3 molecule may hold the potential to provide future epigenetic therapy against inflammation-induced renal injury.

Original languageEnglish
Pages (from-to)362-366
Number of pages5
JournalToxicology Mechanisms and Methods
Volume21
Issue number4
DOIs
Publication statusPublished - May 2011

Fingerprint

Activating Transcription Factor 3
Acute Kidney Injury
Epigenomics
Macrophages
Cytokines
Inflammation
Reperfusion
Ischemia
Kidney
Therapeutics
Leucine Zippers
Endothelial cells
Wounds and Injuries
Cell death
Interleukin-12
Septic Shock
Reperfusion Injury
Chemokines
Interleukin-6
Animals

Keywords

  • ATF3
  • deacetylation
  • Epigenetic therapy
  • kidney injury

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Acute kidney injury and the potential for ATF3-regulated epigenetic therapy. / Cheng, Ching Feng; Lin, Heng.

In: Toxicology Mechanisms and Methods, Vol. 21, No. 4, 05.2011, p. 362-366.

Research output: Contribution to journalArticle

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