Acute flaccid paralysis in infants and young children with enterovirus 71 infection

MR imaging findings and clinical correlates

C. Y. Chen, Y. C. Chang, C. C. Huang, C. C. Lui, K. W. Lee, S. C. Huang

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Enterovirus 71 (EV71) infection is now considered an important cause of childhood acute flaccid paralysis. The purpose of our study was to determine whether EV71-infection-related acute flaccid paralysis in infants and young children has characteristic MR imaging patterns. METHODS: Seven infants and young children with acute paralysis of the upper or lower extremities and positive EV71 cultures underwent spinal MR studies during an outbreak of hand-foot-and-mouth disease in Taiwan in 1998. RESULTS: Acute paralysis was observed in one upper extremity in two patients, in one lower extremity in three patients, and in both lower extremities in two patients. None of the patients had sensory impairment or bulbar palsy. MR studies showed unilateral or bilateral hyperintense lesions in the anterior horn regions of the cord on T2-weighted images in six patients. No abnormal signal was present in one patient. Two of three patients who received intravenous injections of contrast material had ventral root enhancement on T1-weighted images. One of them also had enhancement of the unilateral anterior horn cells. At clinical follow-up, both patients with bilateral anterior horn abnormalities had residual motor weakness, whereas only one of the five patients with unilateral involvement had residual weakness. CONCLUSION: EV71 radiculomyelitis tends to be unilateral and to specifically involve both the anterior horn cells of the cord and the ventral roots. MR imaging allows early detection of spinal cord and root lesions.

Original languageEnglish
Pages (from-to)200-205
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume22
Issue number1
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Enterovirus Infections
Paralysis
Spinal Nerve Roots
Anterior Horn Cells
Lower Extremity
Enterovirus
Horns
Progressive Bulbar Palsy
Hand, Foot and Mouth Disease
Taiwan
Upper Extremity
Intravenous Injections
Contrast Media
Disease Outbreaks
Spinal Cord

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Acute flaccid paralysis in infants and young children with enterovirus 71 infection : MR imaging findings and clinical correlates. / Chen, C. Y.; Chang, Y. C.; Huang, C. C.; Lui, C. C.; Lee, K. W.; Huang, S. C.

In: American Journal of Neuroradiology, Vol. 22, No. 1, 2001, p. 200-205.

Research output: Contribution to journalArticle

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