Acute effects of ephedra on autonomic nervous modulation in healthy young adults

Wei-Lung Chen, T. H. Tsai, C. C H Yang, T. B J Kuo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The aim of this study was to assess the acute effects of ephedra on autonomic nervous modulation by means of heart rate variability (HRV) analysis, using a randomized, double-blind, placebo-controlled, crossover design. On three separate days, 20 healthy subjects took capsules containing either 1 or 2 g of ephedra dry extract or a placebo, and the sequential percentage changes in HRV measures were compared. After the subjects took ephedra, the normalized low-frequency component (LF) and the ratio of LF to high-frequency component (HF) increased significantly in a dose-dependent manner, whereas the normalized HF (HF%) decreased significantly. We conclude that ingestion of ephedra tilts the sympathovagal balance dose-dependently toward increased sympathetic activity and impairs parasympathetic activity.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalClinical Pharmacology and Therapeutics
Volume88
Issue number1
DOIs
Publication statusPublished - Jul 24 2010
Externally publishedYes

Fingerprint

Ephedra
Young Adult
Heart Rate
Placebos
Cross-Over Studies
Capsules
Healthy Volunteers
Eating

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Acute effects of ephedra on autonomic nervous modulation in healthy young adults. / Chen, Wei-Lung; Tsai, T. H.; Yang, C. C H; Kuo, T. B J.

In: Clinical Pharmacology and Therapeutics, Vol. 88, No. 1, 24.07.2010, p. 39-44.

Research output: Contribution to journalArticle

Chen, Wei-Lung ; Tsai, T. H. ; Yang, C. C H ; Kuo, T. B J. / Acute effects of ephedra on autonomic nervous modulation in healthy young adults. In: Clinical Pharmacology and Therapeutics. 2010 ; Vol. 88, No. 1. pp. 39-44.
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