Acute bilateral diffuse corneal opacity in a child

Tsung J. Wang, Cheng Hsiang Hsiao, Fung Rong Hu, I. Jong Wang, Yu Chih Hou

Research output: Contribution to journalArticle

Abstract

PURPOSE: To report a case of acute bilateral corneal opacity related to bacterial blepharoconjunctivitis. METHODS: Interventional case report. An 18-month-old boy had bilateral red eyes with discharge and periorbital eczema. Bilateral corneal opacity suddenly developed 1 week later. RESULTS: All clinical assessments and laboratory evaluations of viral infection and autoimmune profiles were negative except for growth of coagulase-negative staphylococcus and propionibacterium acnes from conjunctival discharge. After systemic and topical antibiotic treatment, the opacity and inflammation of both eyes decreased. The left cornea became clear, but the right eye had a sequela of corneal opacity with stromal neovascularization and conjunctival scarring. Penetrating keratoplasty was performed in the right eye 6 months later. Histology at that time showed neovascularization in the deep stroma with perivascular mononuclear cell infiltration and decreased endothelial cells. CONCLUSIONS: Acute bilateral corneal opacity is rare but may occur in children with bacterial blepharokeratoconjunctivitis. Ocular surface inflammation may be induced by bacterial toxin reaction. Combined use of antibiotics and steroids may save the vision in such patients.

Original languageEnglish
Pages (from-to)375-378
Number of pages4
JournalCornea
Volume26
Issue number3
DOIs
Publication statusPublished - Apr 2007
Externally publishedYes

Fingerprint

Corneal Opacity
Naphazoline
Anti-Bacterial Agents
Inflammation
Bacterial Toxins
Propionibacterium acnes
Penetrating Keratoplasty
Coagulase
Eczema
Virus Diseases
Staphylococcus
Cornea
Cicatrix
Histology
Endothelial Cells
Steroids
Growth

Keywords

  • Bacterial toxin
  • Blepharoconjunctivitis
  • Corneal opacity

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Wang, T. J., Hsiao, C. H., Hu, F. R., Wang, I. J., & Hou, Y. C. (2007). Acute bilateral diffuse corneal opacity in a child. Cornea, 26(3), 375-378. https://doi.org/10.1097/ICO.0b013e31802eaf7a

Acute bilateral diffuse corneal opacity in a child. / Wang, Tsung J.; Hsiao, Cheng Hsiang; Hu, Fung Rong; Wang, I. Jong; Hou, Yu Chih.

In: Cornea, Vol. 26, No. 3, 04.2007, p. 375-378.

Research output: Contribution to journalArticle

Wang, TJ, Hsiao, CH, Hu, FR, Wang, IJ & Hou, YC 2007, 'Acute bilateral diffuse corneal opacity in a child', Cornea, vol. 26, no. 3, pp. 375-378. https://doi.org/10.1097/ICO.0b013e31802eaf7a
Wang, Tsung J. ; Hsiao, Cheng Hsiang ; Hu, Fung Rong ; Wang, I. Jong ; Hou, Yu Chih. / Acute bilateral diffuse corneal opacity in a child. In: Cornea. 2007 ; Vol. 26, No. 3. pp. 375-378.
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