Abstract
Despite some studies having indicated a possible association between appendicitis and duodenal ulcers, this association was mainly based on regional samples or limited clinician experiences, and as such, did not permit unequivocal conclusions. In this case-control study, we examined the association of acute appendicitis with peptic ulcers using a population-based database. We included 3574 patients with acute appendicitis as cases and 3574 sex- and age-matched controls. A Chi-squared test showed that there was a significant difference in the prevalences of prior peptic ulcers between cases and controls (21.7% vs. 16.8%, p <0.001). The adjusted odds ratio (OR) of prior peptic ulcers for cases was 1.40 (95% confidence interval [CI]: 1.24∼1.54, p <0.001) compared to controls. The results further revealed that younger groups demonstrated higher ORs for prior peptic ulcers among cases than controls. In particular, the adjusted OR for cases <30 years old was as high as 1.65 (95% CI = 1.25∼2.19; p <0.001) compared to controls. However, we failed to observe an association of acute appendicitis with peptic ulcers in the ≥60-year age group (OR = 1.19, 95% CI = 0.93∼1.52). We concluded that there is an association between acute appendicitis and a previous diagnosis of peptic ulcers.
| Original language | English |
|---|---|
| Article number | 18044 |
| Journal | Scientific Reports |
| Volume | 5 |
| DOIs | |
| Publication status | Published - Dec 8 2015 |
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Acute appendicitis is associated with peptic ulcers : A population-based study. / Tsai, Ming Chieh; Kao, Li Ting; Lin, Herng Ching; Chung, Shiu Dong; Lee, Cha Ze.
In: Scientific Reports, Vol. 5, 18044, 08.12.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute appendicitis is associated with peptic ulcers
T2 - A population-based study
AU - Tsai, Ming Chieh
AU - Kao, Li Ting
AU - Lin, Herng Ching
AU - Chung, Shiu Dong
AU - Lee, Cha Ze
PY - 2015/12/8
Y1 - 2015/12/8
N2 - Despite some studies having indicated a possible association between appendicitis and duodenal ulcers, this association was mainly based on regional samples or limited clinician experiences, and as such, did not permit unequivocal conclusions. In this case-control study, we examined the association of acute appendicitis with peptic ulcers using a population-based database. We included 3574 patients with acute appendicitis as cases and 3574 sex- and age-matched controls. A Chi-squared test showed that there was a significant difference in the prevalences of prior peptic ulcers between cases and controls (21.7% vs. 16.8%, p <0.001). The adjusted odds ratio (OR) of prior peptic ulcers for cases was 1.40 (95% confidence interval [CI]: 1.24∼1.54, p <0.001) compared to controls. The results further revealed that younger groups demonstrated higher ORs for prior peptic ulcers among cases than controls. In particular, the adjusted OR for cases <30 years old was as high as 1.65 (95% CI = 1.25∼2.19; p <0.001) compared to controls. However, we failed to observe an association of acute appendicitis with peptic ulcers in the ≥60-year age group (OR = 1.19, 95% CI = 0.93∼1.52). We concluded that there is an association between acute appendicitis and a previous diagnosis of peptic ulcers.
AB - Despite some studies having indicated a possible association between appendicitis and duodenal ulcers, this association was mainly based on regional samples or limited clinician experiences, and as such, did not permit unequivocal conclusions. In this case-control study, we examined the association of acute appendicitis with peptic ulcers using a population-based database. We included 3574 patients with acute appendicitis as cases and 3574 sex- and age-matched controls. A Chi-squared test showed that there was a significant difference in the prevalences of prior peptic ulcers between cases and controls (21.7% vs. 16.8%, p <0.001). The adjusted odds ratio (OR) of prior peptic ulcers for cases was 1.40 (95% confidence interval [CI]: 1.24∼1.54, p <0.001) compared to controls. The results further revealed that younger groups demonstrated higher ORs for prior peptic ulcers among cases than controls. In particular, the adjusted OR for cases <30 years old was as high as 1.65 (95% CI = 1.25∼2.19; p <0.001) compared to controls. However, we failed to observe an association of acute appendicitis with peptic ulcers in the ≥60-year age group (OR = 1.19, 95% CI = 0.93∼1.52). We concluded that there is an association between acute appendicitis and a previous diagnosis of peptic ulcers.
UR - http://www.scopus.com/inward/record.url?scp=84949522121&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84949522121&partnerID=8YFLogxK
U2 - 10.1038/srep18044
DO - 10.1038/srep18044
M3 - Article
C2 - 26643405
AN - SCOPUS:84949522121
VL - 5
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 18044
ER -