Active Tumor-Targeted co-Delivery of Epigallocatechin Gallate and Doxorubicin in Nanoparticles for Combination Gastric Cancer Therapy

Fwu Long Mi, Li Fang Wang, Pei Yi Chu, Shin Lei Peng, Chun Lung Feng, Ying Jing Lai, Jia Ni Li, Yu Hsin Lin

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The clinical treatment of gastric cancer is hampered by the development of anticancer drug resistance as well as the unfavorable pharmacokinetics, nontarget toxicity, and inadequate intratumoral accumulation of current chemotherapies. The polyphenol epigallocatechin gallate in combination with doxorubicin exhibits synergistic inhibition P-glycoprotein efflux pump activity and cancer cell growth. This study evaluated a potential activated nanoparticle delivery system comprising a hyaluronic acid complex with polyethylene glycol-conjugated gelatin containing encapsulated epigallocatechin gallate and low-dose doxorubicin, which may facilitate targeted drug administration to gastric cancer cells. We confirmed successful delivery of bioactive combination drugs and internalization into gastric cancer cells through CD44 ligand recognition and ensuing inhibition of cell proliferation via caspase-induced apoptosis and G2/M phase cell cycle arrest. Furthermore, the targeted nanoparticles significantly suppressed gastric tumor activity and reduced both tumor and heart tissue inflammatory reaction in vivo compared to systemic combination treatment.

Original languageEnglish
Pages (from-to)2847-2859
Number of pages13
JournalACS Biomaterials Science and Engineering
Volume4
Issue number8
DOIs
Publication statusPublished - Aug 13 2018

Keywords

  • combination drugs
  • gastric cancer
  • nanoparticles
  • P-glycoprotein
  • synergistic

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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