Activation status of T and NK cells in the endometrium throughout menstrual cycle and normal and abnormal early pregnancy

Hong Nerng Ho, Kuang Han Chao, Chun Kai Chen, Yu Shih Yang, Su Cheng Huang

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Endometrial lymphocytes were studied at all stages throughout the menstrual cycle and early pregnancy by flow cytometry to examine different lymphocyte subpopulations and the expression of the T- and NK-cell activation markers. After pregnancy, CD8 + CD3 + lymphocytes were decreased in the decidua. In both endometrium and decidua, more T cells expressed CD69, CD71, HLA-DR, and CD38 antigens than in peripheral blood. After pregnancy, CD71 + CD3 + lymphocytes were further increased. CD25 + CD3 + lymphocytes decreased significantly in the endometrium and decidua of ectopic pregnancies, but not in the decidua of normal pregnancies. These findings indicate that T cells are regionally activated in the first trimester, and it may be the result of the stimulation by fetal antigens. NK cells were the most abundant cell type in the decidua, which expressed the phenotype CD16 CD56 + , and CD57 CD56 + . The proportion of activated decidual NK cells was increased in anembryonic pregnancies more than in normal pregnancies, although the total NK subpopulation was similar in both groups. This might result in increased NK cytotoxicity in anembryonic pregnancies. In conclusion, T cells are activated, but NK cytotoxicity is decreased in the decidua of early normal pregnancies. This might be important in the control of trophoblast growth and placental development.

Original languageEnglish
Pages (from-to)130-136
Number of pages7
JournalHuman Immunology
Volume49
Issue number2
DOIs
Publication statusPublished - Sep 1 1996
Externally publishedYes

Fingerprint

Menstrual Cycle
Endometrium
Decidua
Natural Killer Cells
T-Lymphocytes
Pregnancy
Lymphocytes
CD38 Antigens
Placentation
Ectopic Pregnancy
Lymphocyte Subsets
Trophoblasts
HLA-DR Antigens
First Pregnancy Trimester
Growth and Development
Flow Cytometry
Phenotype
Antigens

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Activation status of T and NK cells in the endometrium throughout menstrual cycle and normal and abnormal early pregnancy. / Ho, Hong Nerng; Chao, Kuang Han; Chen, Chun Kai; Yang, Yu Shih; Huang, Su Cheng.

In: Human Immunology, Vol. 49, No. 2, 01.09.1996, p. 130-136.

Research output: Contribution to journalArticle

Ho, Hong Nerng ; Chao, Kuang Han ; Chen, Chun Kai ; Yang, Yu Shih ; Huang, Su Cheng. / Activation status of T and NK cells in the endometrium throughout menstrual cycle and normal and abnormal early pregnancy. In: Human Immunology. 1996 ; Vol. 49, No. 2. pp. 130-136.
@article{48bf6e40806f406f8fb664df8b62be08,
title = "Activation status of T and NK cells in the endometrium throughout menstrual cycle and normal and abnormal early pregnancy",
abstract = "Endometrial lymphocytes were studied at all stages throughout the menstrual cycle and early pregnancy by flow cytometry to examine different lymphocyte subpopulations and the expression of the T- and NK-cell activation markers. After pregnancy, CD8 + CD3 + lymphocytes were decreased in the decidua. In both endometrium and decidua, more T cells expressed CD69, CD71, HLA-DR, and CD38 antigens than in peripheral blood. After pregnancy, CD71 + CD3 + lymphocytes were further increased. CD25 + CD3 + lymphocytes decreased significantly in the endometrium and decidua of ectopic pregnancies, but not in the decidua of normal pregnancies. These findings indicate that T cells are regionally activated in the first trimester, and it may be the result of the stimulation by fetal antigens. NK cells were the most abundant cell type in the decidua, which expressed the phenotype CD16 CD56 + , and CD57 CD56 + . The proportion of activated decidual NK cells was increased in anembryonic pregnancies more than in normal pregnancies, although the total NK subpopulation was similar in both groups. This might result in increased NK cytotoxicity in anembryonic pregnancies. In conclusion, T cells are activated, but NK cytotoxicity is decreased in the decidua of early normal pregnancies. This might be important in the control of trophoblast growth and placental development.",
author = "Ho, {Hong Nerng} and Chao, {Kuang Han} and Chen, {Chun Kai} and Yang, {Yu Shih} and Huang, {Su Cheng}",
year = "1996",
month = "9",
day = "1",
doi = "10.1016/0198-8859(96)00120-6",
language = "English",
volume = "49",
pages = "130--136",
journal = "Human Immunology",
issn = "0198-8859",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Activation status of T and NK cells in the endometrium throughout menstrual cycle and normal and abnormal early pregnancy

AU - Ho, Hong Nerng

AU - Chao, Kuang Han

AU - Chen, Chun Kai

AU - Yang, Yu Shih

AU - Huang, Su Cheng

PY - 1996/9/1

Y1 - 1996/9/1

N2 - Endometrial lymphocytes were studied at all stages throughout the menstrual cycle and early pregnancy by flow cytometry to examine different lymphocyte subpopulations and the expression of the T- and NK-cell activation markers. After pregnancy, CD8 + CD3 + lymphocytes were decreased in the decidua. In both endometrium and decidua, more T cells expressed CD69, CD71, HLA-DR, and CD38 antigens than in peripheral blood. After pregnancy, CD71 + CD3 + lymphocytes were further increased. CD25 + CD3 + lymphocytes decreased significantly in the endometrium and decidua of ectopic pregnancies, but not in the decidua of normal pregnancies. These findings indicate that T cells are regionally activated in the first trimester, and it may be the result of the stimulation by fetal antigens. NK cells were the most abundant cell type in the decidua, which expressed the phenotype CD16 CD56 + , and CD57 CD56 + . The proportion of activated decidual NK cells was increased in anembryonic pregnancies more than in normal pregnancies, although the total NK subpopulation was similar in both groups. This might result in increased NK cytotoxicity in anembryonic pregnancies. In conclusion, T cells are activated, but NK cytotoxicity is decreased in the decidua of early normal pregnancies. This might be important in the control of trophoblast growth and placental development.

AB - Endometrial lymphocytes were studied at all stages throughout the menstrual cycle and early pregnancy by flow cytometry to examine different lymphocyte subpopulations and the expression of the T- and NK-cell activation markers. After pregnancy, CD8 + CD3 + lymphocytes were decreased in the decidua. In both endometrium and decidua, more T cells expressed CD69, CD71, HLA-DR, and CD38 antigens than in peripheral blood. After pregnancy, CD71 + CD3 + lymphocytes were further increased. CD25 + CD3 + lymphocytes decreased significantly in the endometrium and decidua of ectopic pregnancies, but not in the decidua of normal pregnancies. These findings indicate that T cells are regionally activated in the first trimester, and it may be the result of the stimulation by fetal antigens. NK cells were the most abundant cell type in the decidua, which expressed the phenotype CD16 CD56 + , and CD57 CD56 + . The proportion of activated decidual NK cells was increased in anembryonic pregnancies more than in normal pregnancies, although the total NK subpopulation was similar in both groups. This might result in increased NK cytotoxicity in anembryonic pregnancies. In conclusion, T cells are activated, but NK cytotoxicity is decreased in the decidua of early normal pregnancies. This might be important in the control of trophoblast growth and placental development.

UR - http://www.scopus.com/inward/record.url?scp=0030248514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030248514&partnerID=8YFLogxK

U2 - 10.1016/0198-8859(96)00120-6

DO - 10.1016/0198-8859(96)00120-6

M3 - Article

C2 - 8872167

AN - SCOPUS:0030248514

VL - 49

SP - 130

EP - 136

JO - Human Immunology

JF - Human Immunology

SN - 0198-8859

IS - 2

ER -