Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress

Tsai Kun Li, Allen Y. Chen, Chiang Yu, Yong Mao, Huimin Wang, Leroy-Fong Liu

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137 Citations (Scopus)


Hydrogen peroxide (H 2O 2), a reactive oxygen species (ROS), is known to induce oxidative stress and apoptosis. U937 cells treated with H 2O 2 were shown to produce high molecular weight (HMW) DNA fragments ~50 to 100 kb in size in

Original languageEnglish
Pages (from-to)1553-1560
Number of pages8
JournalGenes and Development
Issue number12
Publication statusPublished - Jun 15 1999
Externally publishedYes



  • Apoptosis
  • H O
  • Oxidative stress
  • TOP2
  • VM-26

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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