Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress

Tsai Kun Li, Allen Y. Chen, Chiang Yu, Yong Mao, Huimin Wang, Leroy-Fong Liu

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Hydrogen peroxide (H 2O 2), a reactive oxygen species (ROS), is known to induce oxidative stress and apoptosis. U937 cells treated with H 2O 2 were shown to produce high molecular weight (HMW) DNA fragments ~50 to 100 kb in size in

Original languageEnglish
Pages (from-to)1553-1560
Number of pages8
JournalGenes and Development
Volume13
Issue number12
Publication statusPublished - Jun 15 1999
Externally publishedYes

Fingerprint

Type II DNA Topoisomerase
U937 Cells
Hydrogen Peroxide
Reactive Oxygen Species
Oxidative Stress
Molecular Weight
Apoptosis
DNA

Keywords

  • Apoptosis
  • H O
  • Oxidative stress
  • TOP2
  • VM-26

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress. / Li, Tsai Kun; Chen, Allen Y.; Yu, Chiang; Mao, Yong; Wang, Huimin; Liu, Leroy-Fong.

In: Genes and Development, Vol. 13, No. 12, 15.06.1999, p. 1553-1560.

Research output: Contribution to journalArticle

Li, Tsai Kun ; Chen, Allen Y. ; Yu, Chiang ; Mao, Yong ; Wang, Huimin ; Liu, Leroy-Fong. / Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress. In: Genes and Development. 1999 ; Vol. 13, No. 12. pp. 1553-1560.
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