Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats

Ting Ting Yang, Cheng Kuei Chang, Chiung Wen Tsao, Ya Mei Hsu, Chao Tien Hsu, Juei Tang Cheng

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23 Citations (Scopus)

Abstract

Role of muscarinic receptor in the regulation of glucose uptake or lipolysis in adipose tissue remained unclear. In epididymal white adipose tissue (WAT) isolated from Wistar rats, we observed that acetylcholine (ACh) attenuated the insulin-stimulated glucose uptake and the release of glycerol from WAT in a concentration-dependent manner. Using the blockade of specific antagonists, both actions of ACh were characterized mainly due to an activation of M3 receptors. In the presence of various inhibitors for PLC-PKC pathway, ACh-decreased glucose uptake was also reversed. Taken together, these results suggest that muscarinic M3 receptor is involved in the regulation of glucose uptake and/or lipolysis in adipose tissue.

Original languageEnglish
Pages (from-to)57-59
Number of pages3
JournalNeuroscience Letters
Volume451
Issue number1
DOIs
Publication statusPublished - Feb 13 2009
Externally publishedYes

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Keywords

  • Acetylcholine
  • Adipose
  • Glucose uptake
  • Lipolysis
  • Muscarinic receptor

ASJC Scopus subject areas

  • Neuroscience(all)

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