98 Citations (Scopus)

Abstract

Background: Evidence supports that macrophages as well as lymphocytes and their products may be involved in the pathophysiology of psychiatric disorders. Whether patients with bipolar disorder have activation or reduction of immunity during a manic episode remains unclear. Methods: The purpose of this case-control study was to investigate the lymphocyte proliferation to phytohemagglutinin (PHA), concanavalin A, and pokeweed mitogen, and plasma levels of soluble interleukin-2 receptor (sIL2R) and sIL- 6R in patients with bipolar mania (DSM-IIIR). The subjects were 23 physically healthy patients with Young Mania Rating Scale (YMRS) scores ≥26 as well as aged ≤45 years and 23 age- and gender-matched normal control subjects. The above immune variables were measured in acute mania and consequent remission (YMRS scores ≤12) among bipolar patients. Results: The lymphocyte proliferation to PHA and the plasma sIL-2R levels, but not sIL-6R, of bipolar patients were significantly higher in acute mania than in consequent remission. These elevations were not due to differences in medication status. Only in acute mania were the plasma sIL-2R levels of patients significantly higher than control subjects. A positive correlation between the changes of manic severity and plasma sIL-2R levels was observed. Remitted bipolar patients and normal control subjects did not differ in any of these measures. Conclusions: Cell-mediated immunity activation in bipolar mania was demonstrated and may be through a specifically state-dependent immune response.

Original languageEnglish
Pages (from-to)989-994
Number of pages6
JournalBiological Psychiatry
Volume45
Issue number8
DOIs
Publication statusPublished - Apr 15 1999

Fingerprint

Bipolar Disorder
Cellular Immunity
Phytohemagglutinins
Lymphocytes
Pokeweed Mitogens
Interleukin-2 Receptors
Concanavalin A
Psychiatry
Case-Control Studies
Immunity
Macrophages

Keywords

  • Bipolar disorder
  • Cell-mediated immunity
  • Mania
  • Mitogen-induced lymphocyte proliferation
  • Soluble interleukin-2 receptor
  • Soluble interleukin-6 receptor

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Activation of indices of cell-mediated immunity in bipolar mania. / Tsai, Shang Ying; Chen, Kun Po; Yang, Yi Yuan; Chen, Chiao Chicy; Lee, Ju Chin; Singh, Vijendra K.; Leu, Sy Jye C.

In: Biological Psychiatry, Vol. 45, No. 8, 15.04.1999, p. 989-994.

Research output: Contribution to journalArticle

Tsai, Shang Ying ; Chen, Kun Po ; Yang, Yi Yuan ; Chen, Chiao Chicy ; Lee, Ju Chin ; Singh, Vijendra K. ; Leu, Sy Jye C. / Activation of indices of cell-mediated immunity in bipolar mania. In: Biological Psychiatry. 1999 ; Vol. 45, No. 8. pp. 989-994.
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AU - Tsai, Shang Ying

AU - Chen, Kun Po

AU - Yang, Yi Yuan

AU - Chen, Chiao Chicy

AU - Lee, Ju Chin

AU - Singh, Vijendra K.

AU - Leu, Sy Jye C

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N2 - Background: Evidence supports that macrophages as well as lymphocytes and their products may be involved in the pathophysiology of psychiatric disorders. Whether patients with bipolar disorder have activation or reduction of immunity during a manic episode remains unclear. Methods: The purpose of this case-control study was to investigate the lymphocyte proliferation to phytohemagglutinin (PHA), concanavalin A, and pokeweed mitogen, and plasma levels of soluble interleukin-2 receptor (sIL2R) and sIL- 6R in patients with bipolar mania (DSM-IIIR). The subjects were 23 physically healthy patients with Young Mania Rating Scale (YMRS) scores ≥26 as well as aged ≤45 years and 23 age- and gender-matched normal control subjects. The above immune variables were measured in acute mania and consequent remission (YMRS scores ≤12) among bipolar patients. Results: The lymphocyte proliferation to PHA and the plasma sIL-2R levels, but not sIL-6R, of bipolar patients were significantly higher in acute mania than in consequent remission. These elevations were not due to differences in medication status. Only in acute mania were the plasma sIL-2R levels of patients significantly higher than control subjects. A positive correlation between the changes of manic severity and plasma sIL-2R levels was observed. Remitted bipolar patients and normal control subjects did not differ in any of these measures. Conclusions: Cell-mediated immunity activation in bipolar mania was demonstrated and may be through a specifically state-dependent immune response.

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