Activation of IGF-I survival signaling and its compensative inhibition of the cardiac apoptosis on carotid arteries balloon-injured rat hearts

Cheng Hong Hsieh, Peiying Pai, Jia Ping Wu, Tsung Jung Ho, Chieh Hsi Wu, Marthandam Asokan Shibu, Cecilia Hsuan Day, Vijaya Padma Viswanadha, Ho Lin Chuang, Chih Yang Huang

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Abstract

In this study, a rat carotid balloon injury-animal model was used to elucidate the temporal relation of hypertrophy in the progression of cardiac damage and the role of insulin-like growth factor (IGF)-I survival pathway on course of the cardiac damage. Rats were subjected to carotid balloon-injury and examined at different time points. We further studied the heart-weight/body-weight-ratio, histology and protein expression to understand the pathological events associated with percutaneous transluminal coronary angioplasty (PTCA) induced damages. Protein expression analysis showed increased levels of IGF-I signaling pathway and mitogen-activated protein kinase (MAPK) signaling pathway after 2 h and after 2 d of carotid balloon injury. On the other hand, apoptosis signaling pathways were enhanced after 14 d of carotid balloon injury. According to the results, rat carotid balloon injury significantly induced IGF-I survival signaling and compensated hypertrophy pathway during the initial period of injury however after 14 d the proteins involved in apoptotic cell death were elevated and the proteins of the survival pathway and compensatory hypertrophy were significantly reduced.

Original languageEnglish
Pages (from-to)166-173
Number of pages8
JournalChinese Journal of Physiology
Volume60
Issue number3
DOIs
Publication statusPublished - 2017
Externally publishedYes

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Keywords

  • Cardiac apoptosis
  • Compensated hypertrophy
  • Decompensated hypertrophy
  • IGF-I survival pathway
  • Percutaneous transluminal coronary angioplasty

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Hsieh, C. H., Pai, P., Wu, J. P., Ho, T. J., Wu, C. H., Shibu, M. A., Day, C. H., Viswanadha, V. P., Chuang, H. L., & Huang, C. Y. (2017). Activation of IGF-I survival signaling and its compensative inhibition of the cardiac apoptosis on carotid arteries balloon-injured rat hearts. Chinese Journal of Physiology, 60(3), 166-173. https://doi.org/10.4077/CJP.2017.BAF455