Activation of gonadotropin-releasing hormone receptors produces neuronal excitation in the rat hippocampus

Farn Lu, Jung Mou Yang, Jian Nan Wu, Yao Chung Chen, Yu Hsun Kao, Che Se Tung, San Nan Yang

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Abstract

Whole-cell patch-clamp recordings of evoked action potentials were made in CA1 and CA3 pyramidal neurons of rat hippocampal slices. Previously we have demonstrated that activation of gonadotropin-releasing hormone (GnRH) receptors induces a long-lasting enhancement of synaptic transmission mediated by ionotropic glutamate receptors in CA1 pyramidal neurons of rat hippocampal slices. Here, we further studied whether activation of GnRH receptors could modulate intrinsic neuronal excitability in CA1 and CA3 pyramidal neurons of rat hippocampal slices. The use of a specific GnRH analog, leuprolide (10-8 M), elicited a relatively long-term increase in evoked action potentials in CA1 and CA3 pyramidal neurons, respectively. The GnRH receptor-induced increase in evoked action potentials in both CA1 and CA3 pyramidal neurons could be abolished by a potent GnRH receptor antagonist, [acetyl-3,4-dehydro-Pro1,D-p-F-Phe2,D-Trp 3,6]-LHRH (10-8 M). The present study suggests that activation of GnRH receptors can lead to an increase of intrinsic neuronal excitability of both CA1 and CA3 pyramidal neurons in the rat hippocampus, an important integrative region for reproductive process, both endocrinologically and behaviorally.

Original languageEnglish
Pages (from-to)67-71
Number of pages5
JournalChinese Journal of Physiology
Volume42
Issue number2
Publication statusPublished - 1999
Externally publishedYes

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Keywords

  • CA1 neurons
  • CA3 neurons
  • Gonadotropin-releasing hormone receptor
  • Hippocampus
  • Leuprolide
  • Neuropeptide

ASJC Scopus subject areas

  • Physiology

Cite this

Lu, F., Yang, J. M., Wu, J. N., Chen, Y. C., Kao, Y. H., Tung, C. S., & Yang, S. N. (1999). Activation of gonadotropin-releasing hormone receptors produces neuronal excitation in the rat hippocampus. Chinese Journal of Physiology, 42(2), 67-71.