Activating transcription factor 3, an early cellular adaptive responder in ischemia/reperfusion-induced injury

Heng Lin, Ching Feng Cheng

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

Recent studies have reported that ischemia/reperfusion (I/R) may act in the immune system where an exaggerated inflammatory response is initiated. With the activation of the immune system, damage-associated molecular patterns migrate and adhere to the I/R region, consequently inducing multiorgan injury. Emerging data indicate that upon I/R, stress-inducible proteins, including activating transcription factor 3 (ATF3), play essential roles in signaling during antiapoptotic, antimigration, and anti-inflammatory processes. Accumulating data suggest that ATF3 may be a potential target in I/R- or inflammation-induced organ dysfunction. This minireview focuses on the emerging evidence of the roles of ATF3 in multiple organs including the kidney, myocardium, and brain following I/R injury. In addition, this review addresses the role of ATF3 in chronic inflammation-induced pathophysiologies such as diabetes and atherosclerosis.

Original languageEnglish
Pages (from-to)61-65
Number of pages5
JournalTzu Chi Medical Journal
Volume30
Issue number2
DOIs
Publication statusPublished - 2018

Keywords

  • Activating transcription factor 3
  • Ischemia
  • Reperfusion

ASJC Scopus subject areas

  • Medicine(all)

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