Actions of Thyroid Hormone Analogues on Chemokines

Paul J. Davis, Gennadi V. Glinsky, Hung Yun Lin, Shaker A. Mousa

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

The extracellular domain of plasma membrane integrin αvβ3 contains a receptor for thyroid hormone (L-thyroxine, T4; 3,5,3′-triiodo-L-thyronine, T3); this receptor also binds tetraiodothyroacetic acid (tetrac), a derivative of T4. Tetrac inhibits the binding of T4 and T3 to the integrin. Fractalkine (CX3CL1) is a chemokine relevant to inflammatory processes in the CNS that are microglia-dependent but also important to normal brain development. Expression of the CX3CL1 gene is downregulated by tetrac, suggesting that T4 and T3 may stimulate fractalkine expression. Independently of its specific receptor (CX3CR1), fractalkine binds to αvβ3 at a site proximal to the thyroid hormone-tetrac receptor and changes the physical state of the integrin. Tetrac also affects expression of the genes for other CNS-relevant chemokines, including CCL20, CCL26, CXCL2, CXCL3, and CXCL10. The chemokine products of these genes are important to vascularity of the brain, particularly of the choroid plexus, to inflammatory processes in the CNS and, in certain cases, to neuroprotection. Thyroid hormones are known to contribute to regulation of each of these CNS functions. We propose that actions of thyroid hormone and hormone analogues on chemokine gene expression contribute to regulation of inflammatory processes in brain and of brain blood vessel formation and maintenance.

Original languageEnglish
Article number3147671
JournalJournal of Immunology Research
Volume2016
DOIs
Publication statusPublished - 2016

Fingerprint

Thyroid Hormones
Chemokines
Chemokine CX3CL1
Integrins
Brain
Gene Expression
Chemokine CCL20
Thyronines
Thyroid Hormone Receptors
Choroid Plexus
Microglia
Thyroxine
Blood Vessels
Down-Regulation
Maintenance
Cell Membrane
tetraiodothyroacetic acid
Hormones
Genes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Actions of Thyroid Hormone Analogues on Chemokines. / Davis, Paul J.; Glinsky, Gennadi V.; Lin, Hung Yun; Mousa, Shaker A.

In: Journal of Immunology Research, Vol. 2016, 3147671, 2016.

Research output: Contribution to journalReview article

Davis, Paul J. ; Glinsky, Gennadi V. ; Lin, Hung Yun ; Mousa, Shaker A. / Actions of Thyroid Hormone Analogues on Chemokines. In: Journal of Immunology Research. 2016 ; Vol. 2016.
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