Action mechanism of Ginkgo biloba leaf extract intervened by exercise therapy in treatment of benign prostate hyperplasia

Chiung Chi Peng, Jia Hong Liu, Chi Huang Chang, Jin Yuan Chung, Kuan Chou Chen, Kuang Yu Chou, Robert Y. Peng

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Benign prostatic hyperplasia (BPH), an imbalance between androgen/estrogen, overexpression of stromal, and epithelial growth factors associated with chronic inflammation, has become an atypical direct cause of mortality of aged male diseases. Ginkgo possesses anti-inflammatory, blood flow-enhancing, and free radical scavenging effects. Considering strenuous exercise can reduce BPH risks, we hypothesize Ginkgo + exercise (Ginkgo + Ex) could be beneficial to BPH. To verify this, rat BPH model was induced by s.c. 3.5 mg testosterone (T) and 0.1 mg estradiol (E2) per head per day successively for 8 weeks, using mineral oil as placebo. Cerenin® 8.33 L/100 g was applied s.c. from the 10th to the 13th week, and simultaneously, Ex was applied (30 m/min, 3 times/week). In BPH, Ginkgo alone had no effect on T, 5α-reductase, and dihydrotestosterone (DHT), but suppressed androgen receptor (AR), aromatase, E2 and estrogen receptor (ER), and the proliferating cell nuclear antigen (PCNA); Ex alone significantly reduced T, aromatase, E2, ER, AR, and PCNA, but highly raised DHT. While Ginkgo + Ex androgenically downregulated T, aromatase, E2, and ER, but upregulated DHT, AR, and PCNA, implying Ginkgo + Ex tended to worsen BPH. Conclusively, Ginkgo or Ex alone may be more beneficial than Ginkgo + Ex for treatment of BPH.

Original languageEnglish
Article number408734
JournalEvidence-based Complementary and Alternative Medicine
Volume2013
DOIs
Publication statusPublished - 2013

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Exercise Therapy
Ginkgo biloba
Prostatic Hyperplasia
Hyperplasia
Prostate
Androgen Receptors
Aromatase
Proliferating Cell Nuclear Antigen
Estrogen Receptors
Dihydrotestosterone
Therapeutics
Mineral Oil
Androgens
Free Radicals
Testosterone
Estradiol
Intercellular Signaling Peptides and Proteins
Oxidoreductases
Estrogens
Anti-Inflammatory Agents

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Action mechanism of Ginkgo biloba leaf extract intervened by exercise therapy in treatment of benign prostate hyperplasia. / Peng, Chiung Chi; Liu, Jia Hong; Chang, Chi Huang; Chung, Jin Yuan; Chen, Kuan Chou; Chou, Kuang Yu; Peng, Robert Y.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2013, 408734, 2013.

Research output: Contribution to journalArticle

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