Acrokeratosis paraneoplastica (Bazex syndrome) with adenocarcinoma of the colon: Report of a case and review of the literature

Yao Shih Hsu, Gi Shih Lien, Hsien Hung Lai, Yeong Shan Cheng, Chung Hong Hu, Mao Chih Hsieh, Chia Lang Fang, Shiann Pan

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Acrokeratosis paraneoplastica is a rare disease and is uncommon even in patients with upper aerodigestive tract cancer. We report a 63-year-old man with a 1-month history of numerous pruritic lesions and vesicles on both feet. Although he had received local therapy, progressive dense scale formation involving both palms and both soles was found. Colonoscopy was performed because of hematochezia, and it revealed an early colon cancer. After the resection of the cancer, the skin lesions began to fall off dramatically. To the best of our knowledge, there is no report of acrokeratosis paraneoplastica associated with colon cancer in the literature. This is the first case report of acrokeratosis paraneoplastica associated with early colon cancer.

Original languageEnglish
Pages (from-to)460-464
Number of pages5
JournalJournal of Gastroenterology
Issue number6
Publication statusPublished - Jan 1 2000



  • Acrokeratosis paraneoplastica
  • Bazex syndrome
  • Colon cancer

ASJC Scopus subject areas

  • Gastroenterology

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