Acquired XO/XY clones in bone marrow of a patient with paroxysmal nocturnal hemoglobinuria (PNH)

J. Whang Peng, T. Knutsen, E. C. Lee, B. Leventhal

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9 Citations (Scopus)

Abstract

Cytogenetic studies showed both 45XO and 46XY clones in the bone marrow of a 76 yr old male with a 17 yr history of paroxysmal nocturnal hemoglobinuria (PNH). 55Fe incorporation studies demonstrated that both clones involved the hematopoietic stem cells. The loss of the Y chromosome may reflect an aging phenomenon, rather than be related to the PNH.

Original languageEnglish
Pages (from-to)611-619
Number of pages9
JournalBlood
Volume47
Issue number4
Publication statusPublished - Dec 1 1976
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology
  • Biochemistry
  • Hematology
  • Cell Biology

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