Acquired pulmonary vein stenosis after radiofrequency catheter ablation of paroxysmal atrial fibrillation

Wen Chung Yu, Tsui Lieh Hsu, Ching Tai Tai, Chin Feng Tsai, Ming Hsiung Hsieh, Wei Shiang Lin, Yung Kuo Lin, Hsuan Ming Tsao, Ding Yu-An, Mau Song Chang, Shih Ann Chen

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

Introduction: Elimination of the initiating focus within the pulmonary vein (PV) using radiofrequency (RF) catheter ablation is a new treatment modality for treatment of drug-refractory atrial fibrillation. However, information on the long-term safety of RF ablation within the PV is limited. Methods and Results: In 102 patients with drug-refractory atrial fibrillation and at least one initiating focus from the PV, series transesophageal echocardiography was performed to monitor the effect of RF ablation on the PV. There were 66 foci in the right upper PV and 65 foci in the left upper PV. Within 3 days of ablation, 26 of the ablated right upper PVs (39%) had increased peak Doppler flow velocity (mean 130 ± 28 cm/sec, range 106 to 220), and 15 of the ablated left upper PVs (23%) had increased peak Doppler flow velocity (mean 140 ± 39 cm/sec, range 105 to 219). Seven patients had increased peak Doppler flow velocity in both upper PVs. No factor (including age, sex, site of ablation, number of RF pulses, pulse duration, and temperature) could predict PV stenosis after RF ablation. Three patients with stenosis of both upper PVs experienced mild dyspnea on exertion, but only one had mild increase of pulmonary pressure. There was no significant change of peak and mean flow velocity and of PV diameter in sequential follow-up studies up to 16 (209 ± 94) months. Conclusion: Focal PV stenosis is observed frequently after RF catheter ablation applied within the vein, but usually is without clinical significance. However, ablation within multiple PVs might cause pulmonary hypertension and should be considered a limiting factor in this procedure.

Original languageEnglish
Pages (from-to)887-892
Number of pages6
JournalJournal of Cardiovascular Electrophysiology
Volume12
Issue number8
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Catheter Ablation
Pulmonary Veins
Atrial Fibrillation
Age Factors
Transesophageal Echocardiography
Pulmonary Vein Stenosis
Pulmonary Hypertension
Pharmaceutical Preparations
Dyspnea
Veins
Pathologic Constriction
Safety
Pressure
Lung
Temperature
Therapeutics

Keywords

  • Atrial fibrillation
  • Pulmonary vein stenosis
  • Radiofrequency catheter ablation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Acquired pulmonary vein stenosis after radiofrequency catheter ablation of paroxysmal atrial fibrillation. / Yu, Wen Chung; Hsu, Tsui Lieh; Tai, Ching Tai; Tsai, Chin Feng; Hsieh, Ming Hsiung; Lin, Wei Shiang; Lin, Yung Kuo; Tsao, Hsuan Ming; Yu-An, Ding; Chang, Mau Song; Chen, Shih Ann.

In: Journal of Cardiovascular Electrophysiology, Vol. 12, No. 8, 2001, p. 887-892.

Research output: Contribution to journalArticle

Yu, WC, Hsu, TL, Tai, CT, Tsai, CF, Hsieh, MH, Lin, WS, Lin, YK, Tsao, HM, Yu-An, D, Chang, MS & Chen, SA 2001, 'Acquired pulmonary vein stenosis after radiofrequency catheter ablation of paroxysmal atrial fibrillation', Journal of Cardiovascular Electrophysiology, vol. 12, no. 8, pp. 887-892.
Yu, Wen Chung ; Hsu, Tsui Lieh ; Tai, Ching Tai ; Tsai, Chin Feng ; Hsieh, Ming Hsiung ; Lin, Wei Shiang ; Lin, Yung Kuo ; Tsao, Hsuan Ming ; Yu-An, Ding ; Chang, Mau Song ; Chen, Shih Ann. / Acquired pulmonary vein stenosis after radiofrequency catheter ablation of paroxysmal atrial fibrillation. In: Journal of Cardiovascular Electrophysiology. 2001 ; Vol. 12, No. 8. pp. 887-892.
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T1 - Acquired pulmonary vein stenosis after radiofrequency catheter ablation of paroxysmal atrial fibrillation

AU - Yu, Wen Chung

AU - Hsu, Tsui Lieh

AU - Tai, Ching Tai

AU - Tsai, Chin Feng

AU - Hsieh, Ming Hsiung

AU - Lin, Wei Shiang

AU - Lin, Yung Kuo

AU - Tsao, Hsuan Ming

AU - Yu-An, Ding

AU - Chang, Mau Song

AU - Chen, Shih Ann

PY - 2001

Y1 - 2001

N2 - Introduction: Elimination of the initiating focus within the pulmonary vein (PV) using radiofrequency (RF) catheter ablation is a new treatment modality for treatment of drug-refractory atrial fibrillation. However, information on the long-term safety of RF ablation within the PV is limited. Methods and Results: In 102 patients with drug-refractory atrial fibrillation and at least one initiating focus from the PV, series transesophageal echocardiography was performed to monitor the effect of RF ablation on the PV. There were 66 foci in the right upper PV and 65 foci in the left upper PV. Within 3 days of ablation, 26 of the ablated right upper PVs (39%) had increased peak Doppler flow velocity (mean 130 ± 28 cm/sec, range 106 to 220), and 15 of the ablated left upper PVs (23%) had increased peak Doppler flow velocity (mean 140 ± 39 cm/sec, range 105 to 219). Seven patients had increased peak Doppler flow velocity in both upper PVs. No factor (including age, sex, site of ablation, number of RF pulses, pulse duration, and temperature) could predict PV stenosis after RF ablation. Three patients with stenosis of both upper PVs experienced mild dyspnea on exertion, but only one had mild increase of pulmonary pressure. There was no significant change of peak and mean flow velocity and of PV diameter in sequential follow-up studies up to 16 (209 ± 94) months. Conclusion: Focal PV stenosis is observed frequently after RF catheter ablation applied within the vein, but usually is without clinical significance. However, ablation within multiple PVs might cause pulmonary hypertension and should be considered a limiting factor in this procedure.

AB - Introduction: Elimination of the initiating focus within the pulmonary vein (PV) using radiofrequency (RF) catheter ablation is a new treatment modality for treatment of drug-refractory atrial fibrillation. However, information on the long-term safety of RF ablation within the PV is limited. Methods and Results: In 102 patients with drug-refractory atrial fibrillation and at least one initiating focus from the PV, series transesophageal echocardiography was performed to monitor the effect of RF ablation on the PV. There were 66 foci in the right upper PV and 65 foci in the left upper PV. Within 3 days of ablation, 26 of the ablated right upper PVs (39%) had increased peak Doppler flow velocity (mean 130 ± 28 cm/sec, range 106 to 220), and 15 of the ablated left upper PVs (23%) had increased peak Doppler flow velocity (mean 140 ± 39 cm/sec, range 105 to 219). Seven patients had increased peak Doppler flow velocity in both upper PVs. No factor (including age, sex, site of ablation, number of RF pulses, pulse duration, and temperature) could predict PV stenosis after RF ablation. Three patients with stenosis of both upper PVs experienced mild dyspnea on exertion, but only one had mild increase of pulmonary pressure. There was no significant change of peak and mean flow velocity and of PV diameter in sequential follow-up studies up to 16 (209 ± 94) months. Conclusion: Focal PV stenosis is observed frequently after RF catheter ablation applied within the vein, but usually is without clinical significance. However, ablation within multiple PVs might cause pulmonary hypertension and should be considered a limiting factor in this procedure.

KW - Atrial fibrillation

KW - Pulmonary vein stenosis

KW - Radiofrequency catheter ablation

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