Aconitamide, a novel alkaloid from the roots of Aconitum carmichaeli

Zong-Huei Li, Yu Chang Chen, Ching Kuo Lee, Hsun Shuo Chang, Ching Chuan Kuo, Che Yi Chao, Jing Jer Lin, Lee Chiang Lo, Yueh Hsiung Kuo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aconitum carmichaeli Debx. is a traditional Chinese medicine commonly employed for curing a wide array of diseases in East Asia. From the ethyl acetate soluble fraction of the methanolic extracts of A. carmichaeli, a new alkaloid, aconitamide (1), along with eighteen known compounds 2-19 were isolated by column chromatography and identified on the basis of spectroscopic analyses. The anti-telomerase activity of 1-19 was also assessed, but no activity was found, even at a concentration higher than 30 μM.

Original languageEnglish
Pages (from-to)827-828
Number of pages2
JournalNatural Product Communications
Volume8
Issue number6
Publication statusPublished - 2013

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Keywords

  • Aconitamide
  • Aconitum carmichaeli Debx.
  • Anti-telomerase
  • Chinese herb
  • Ranunculaceae
  • Roots

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Complementary and alternative medicine
  • Plant Science

Cite this

Li, Z-H., Chen, Y. C., Lee, C. K., Chang, H. S., Kuo, C. C., Chao, C. Y., Lin, J. J., Lo, L. C., & Kuo, Y. H. (2013). Aconitamide, a novel alkaloid from the roots of Aconitum carmichaeli. Natural Product Communications, 8(6), 827-828.