Acetaminophen overdose in children and adolescents

Syh Jae Lin, H.C Chao, J.L Huang, K.H. Hsieh, Tzou-Yien Lin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

From 1982 to 1997, 12 Chinese children were admitted to Chang Gung Memorial Hospital with acetaminophen overdose. Six subjects (one young child, and five adolescents) developed liver damage which was severe in three cases (AST>1000 IU/L). Acetaminophen-induced liver function abnormalities were characterized by elevation of transaminase levels with ALT higher than AST(6/6), coagulopathy(5/6), thrombocytopenia (1/6), but absence of jaundice(6/6). Fortunately, none of the six patients with liver damage developed fulminant liver failure, and all recovered completely. Acetaminophen overdose can cause significant morbidity in children and adolescents. Caretakers should be well instructed to give the drug correctly. So far, acetaminophen is still considered as the drug-of-choice for antipyresis in pediatric practice. However, multicentered collaborative study is necessary to determine whether acetaminophen intoxication causes less hepatic failure in Chinese children than in Western children.

Original languageEnglish
Pages (from-to)448-453
Number of pages6
JournalActa Paediatrica Sinica
Volume38
Issue number6
Publication statusPublished - 1997
Externally publishedYes

Keywords

  • Acetaminophen overdose
  • Drug intoxication
  • Hepatotoxicity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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