Accuracy of whole-body FDG-PET and FDG-PET/CT in M staging of nasopharyngeal carcinoma

A systematic review and meta-analysis

Ming Che Chang, Jin Hua Chen, Ji An Liang, Kuang Tao Yang, Kai Yuan Cheng, Chia Hung Kao

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: A meta-analysis was conducted to evaluate the accuracy of whole-body positron emission tomography (PET) or PET/CT in M staging of nasopharyngeal carcinoma (NPC). Methods: Through a search of relevant English language studies from October 1996 to September 2011, pooled estimated sensitivity, specificity, positive likelihood ratios, negative likelihood ratios, and summary receiver operating characteristic (SROC) curves of whole-body PET or PET/CT in M staging of NPC were calculated. Results: Three PET and 5 PET/CT studies were identified. The pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of FDG-PET or PET/CT were 0.83 (95% confidence interval [CI], 0.77-0.88), 0.97 (95% CI, 0.95-0.98), 23.38 (95% CI, 16.22-33.69), and 0.19 (95% CI, 0.13-0.25), respectively. The area under curve was 0.9764 and Q* index estimate was 0.9307 for FDG-PET or PET/CT. Conclusion: Current evidence confirms the good diagnostic performance of the whole-body FDG-PET or PET/CT in M staging of NPC.

Original languageEnglish
Pages (from-to)366-373
Number of pages8
JournalEuropean Journal of Radiology
Volume82
Issue number2
DOIs
Publication statusPublished - Feb 2013
Externally publishedYes

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Positron-Emission Tomography
Meta-Analysis
Confidence Intervals
Nasopharyngeal carcinoma
Sensitivity and Specificity
ROC Curve
Area Under Curve
Language

Keywords

  • Meta-analysis
  • Nasopharyngeal carcinoma
  • PET
  • PET/CT
  • Staging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Accuracy of whole-body FDG-PET and FDG-PET/CT in M staging of nasopharyngeal carcinoma : A systematic review and meta-analysis. / Chang, Ming Che; Chen, Jin Hua; Liang, Ji An; Yang, Kuang Tao; Cheng, Kai Yuan; Kao, Chia Hung.

In: European Journal of Radiology, Vol. 82, No. 2, 02.2013, p. 366-373.

Research output: Contribution to journalArticle

Chang, Ming Che ; Chen, Jin Hua ; Liang, Ji An ; Yang, Kuang Tao ; Cheng, Kai Yuan ; Kao, Chia Hung. / Accuracy of whole-body FDG-PET and FDG-PET/CT in M staging of nasopharyngeal carcinoma : A systematic review and meta-analysis. In: European Journal of Radiology. 2013 ; Vol. 82, No. 2. pp. 366-373.
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