Accuracy of three diagnostic tests used alone and in combination for detecting Helicobacter pylori infection in patients with bleeding gastric ulcers

Chien Chung Liao, Chia Long Lee, Yung Chih Lai, Shih Hung Huang, Shui Cheng Lee, Chi Hwa Wu, Tien Chien Tu, Tzen Kwan Chen, Chyi Huey Bai

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective. Accuracy of diagnostic methods for detecting Helicobacter pylori (H. pylori) infection among patients with bleeding peptic ulcers has not been thoroughly investigated. The aim of this study was to compare the diagnostic tests and their combined usage in detection of H. pylori infection in patients with bleeding gastric ulcers and without the use of nonsteroidal anti-inflammatory drugs. Methods. A total of 57 patients who presented with bleeding gastric ulcers by endoscopy were enrolled. The status of H. pylori was identified by performing the rapid urease test (RUT), histology and 13C-labeled urea breath test (UBT). The criteria for having H. pylori infection was a minimum of two positive tests. Results. The prevalence of H. pylori infection in our patient group was 80.7%. Among the three tests used: RUT, histology, and UBT, sensitivities were 56.5%, 97.8% and 100%, while specificities were 100%, 45.5% and 81.8%, respectively. The overall accuracies of the tests were 78.3%, 71.6% and 90.9%, respectively. Although UBT obtained significantly higher accuracy than histology (P=0.02) as opposed to RUT (P=0.11), UBT had significantly higher sensitivity than RUT (P

Original languageEnglish
Pages (from-to)1821-1826
Number of pages6
JournalChinese Medical Journal
Volume116
Issue number12
Publication statusPublished - Dec 2003
Externally publishedYes

Fingerprint

Helicobacter Infections
Stomach Ulcer
Routine Diagnostic Tests
Helicobacter pylori
Breath Tests
Urease
Urea
Hemorrhage
Histology
Peptic Ulcer
Endoscopy
Anti-Inflammatory Agents
Pharmaceutical Preparations

Keywords

  • Breath test
  • Diagnostic test
  • Gastric ulcer
  • Helicobacter pylori

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Accuracy of three diagnostic tests used alone and in combination for detecting Helicobacter pylori infection in patients with bleeding gastric ulcers. / Liao, Chien Chung; Lee, Chia Long; Lai, Yung Chih; Huang, Shih Hung; Lee, Shui Cheng; Wu, Chi Hwa; Tu, Tien Chien; Chen, Tzen Kwan; Bai, Chyi Huey.

In: Chinese Medical Journal, Vol. 116, No. 12, 12.2003, p. 1821-1826.

Research output: Contribution to journalArticle

Liao, Chien Chung ; Lee, Chia Long ; Lai, Yung Chih ; Huang, Shih Hung ; Lee, Shui Cheng ; Wu, Chi Hwa ; Tu, Tien Chien ; Chen, Tzen Kwan ; Bai, Chyi Huey. / Accuracy of three diagnostic tests used alone and in combination for detecting Helicobacter pylori infection in patients with bleeding gastric ulcers. In: Chinese Medical Journal. 2003 ; Vol. 116, No. 12. pp. 1821-1826.
@article{58144a8ec6d046c785b6dfff8499bbd3,
title = "Accuracy of three diagnostic tests used alone and in combination for detecting Helicobacter pylori infection in patients with bleeding gastric ulcers",
abstract = "Objective. Accuracy of diagnostic methods for detecting Helicobacter pylori (H. pylori) infection among patients with bleeding peptic ulcers has not been thoroughly investigated. The aim of this study was to compare the diagnostic tests and their combined usage in detection of H. pylori infection in patients with bleeding gastric ulcers and without the use of nonsteroidal anti-inflammatory drugs. Methods. A total of 57 patients who presented with bleeding gastric ulcers by endoscopy were enrolled. The status of H. pylori was identified by performing the rapid urease test (RUT), histology and 13C-labeled urea breath test (UBT). The criteria for having H. pylori infection was a minimum of two positive tests. Results. The prevalence of H. pylori infection in our patient group was 80.7{\%}. Among the three tests used: RUT, histology, and UBT, sensitivities were 56.5{\%}, 97.8{\%} and 100{\%}, while specificities were 100{\%}, 45.5{\%} and 81.8{\%}, respectively. The overall accuracies of the tests were 78.3{\%}, 71.6{\%} and 90.9{\%}, respectively. Although UBT obtained significantly higher accuracy than histology (P=0.02) as opposed to RUT (P=0.11), UBT had significantly higher sensitivity than RUT (P",
keywords = "Breath test, Diagnostic test, Gastric ulcer, Helicobacter pylori",
author = "Liao, {Chien Chung} and Lee, {Chia Long} and Lai, {Yung Chih} and Huang, {Shih Hung} and Lee, {Shui Cheng} and Wu, {Chi Hwa} and Tu, {Tien Chien} and Chen, {Tzen Kwan} and Bai, {Chyi Huey}",
year = "2003",
month = "12",
language = "English",
volume = "116",
pages = "1821--1826",
journal = "Chinese Medical Journal",
issn = "0366-6999",
publisher = "Chinese Medical Association",
number = "12",

}

TY - JOUR

T1 - Accuracy of three diagnostic tests used alone and in combination for detecting Helicobacter pylori infection in patients with bleeding gastric ulcers

AU - Liao, Chien Chung

AU - Lee, Chia Long

AU - Lai, Yung Chih

AU - Huang, Shih Hung

AU - Lee, Shui Cheng

AU - Wu, Chi Hwa

AU - Tu, Tien Chien

AU - Chen, Tzen Kwan

AU - Bai, Chyi Huey

PY - 2003/12

Y1 - 2003/12

N2 - Objective. Accuracy of diagnostic methods for detecting Helicobacter pylori (H. pylori) infection among patients with bleeding peptic ulcers has not been thoroughly investigated. The aim of this study was to compare the diagnostic tests and their combined usage in detection of H. pylori infection in patients with bleeding gastric ulcers and without the use of nonsteroidal anti-inflammatory drugs. Methods. A total of 57 patients who presented with bleeding gastric ulcers by endoscopy were enrolled. The status of H. pylori was identified by performing the rapid urease test (RUT), histology and 13C-labeled urea breath test (UBT). The criteria for having H. pylori infection was a minimum of two positive tests. Results. The prevalence of H. pylori infection in our patient group was 80.7%. Among the three tests used: RUT, histology, and UBT, sensitivities were 56.5%, 97.8% and 100%, while specificities were 100%, 45.5% and 81.8%, respectively. The overall accuracies of the tests were 78.3%, 71.6% and 90.9%, respectively. Although UBT obtained significantly higher accuracy than histology (P=0.02) as opposed to RUT (P=0.11), UBT had significantly higher sensitivity than RUT (P

AB - Objective. Accuracy of diagnostic methods for detecting Helicobacter pylori (H. pylori) infection among patients with bleeding peptic ulcers has not been thoroughly investigated. The aim of this study was to compare the diagnostic tests and their combined usage in detection of H. pylori infection in patients with bleeding gastric ulcers and without the use of nonsteroidal anti-inflammatory drugs. Methods. A total of 57 patients who presented with bleeding gastric ulcers by endoscopy were enrolled. The status of H. pylori was identified by performing the rapid urease test (RUT), histology and 13C-labeled urea breath test (UBT). The criteria for having H. pylori infection was a minimum of two positive tests. Results. The prevalence of H. pylori infection in our patient group was 80.7%. Among the three tests used: RUT, histology, and UBT, sensitivities were 56.5%, 97.8% and 100%, while specificities were 100%, 45.5% and 81.8%, respectively. The overall accuracies of the tests were 78.3%, 71.6% and 90.9%, respectively. Although UBT obtained significantly higher accuracy than histology (P=0.02) as opposed to RUT (P=0.11), UBT had significantly higher sensitivity than RUT (P

KW - Breath test

KW - Diagnostic test

KW - Gastric ulcer

KW - Helicobacter pylori

UR - http://www.scopus.com/inward/record.url?scp=0742271647&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0742271647&partnerID=8YFLogxK

M3 - Article

VL - 116

SP - 1821

EP - 1826

JO - Chinese Medical Journal

JF - Chinese Medical Journal

SN - 0366-6999

IS - 12

ER -