Absorption and fluorescence spectral properties of hematoporphyrin in liposomes, micelles, and nanoparticles

Yu Tsai Yang, Chin Tin Chen, Tsuimin Tsai

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A model photosensitizer, hematoporphyrin (Hp), encapsulated in various nanocarriers was investigated for both absorption and fluorescence properties. The generation of singlet oxygen upon light activation was also studied. The absorption intensity of nanoencapsulated hematoporphyrin was stronger and exhibited a red-shift of the Soret and Q absorption bands compared to the non-encapsulated hematoporphyrin. The fluorescence spectral changes were similar to the absorption spectral pattern. The generation of singlet oxygen for encapsulated hematoporphyrin upon light activation differed significantly from the free form hematoporphyrin, and the yield of singlet oxygen production was found in the following order: liposomes > micelles ≈ nanoparticles > free Hp. Under the current studied conditions, the use of nanocarriers significantly improve the photophysical properties of hematoporphyrin in aqueous solutions, and the liposome was the optimum system than either the micelle or the nanoparticle.

Original languageEnglish
Pages (from-to)763-769
Number of pages7
JournalDyes and Pigments
Volume96
Issue number3
DOIs
Publication statusPublished - Mar 2013

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Keywords

  • Absorption
  • Emission
  • Hematoporphyrin
  • Liposomes
  • Micelles
  • Nanoparticles

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Process Chemistry and Technology

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