Abnormal functional–structural cingulum connectivity in mania: combined functional magnetic resonance imaging-diffusion tensor imaging investigation in different phases of bipolar disorder

M. Martino, P. Magioncalda, C. Saiote, B. Conio, A. Escelsior, G. Rocchi, N. Piaggio, V. Marozzi, Z. Huang, F. Ferri, M. Amore, M. Inglese, Georg Northoff

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: The objective of the study was to investigate the relationship between structural connectivity (SC) and functional connectivity (FC) in the cingulum in bipolar disorder (BD) and its various phases. Method: We combined resting-state functional magnetic resonance imaging and probabilistic tractographic diffusion tensor imaging to investigate FC and SC of the cingulum and its portions, the SC–FC relationship, and their correlations with clinical and neurocognitive measures on sustained attention in manic (n = 21), depressed (n = 20), and euthymic (n = 20) bipolar patients and healthy controls (HC) (n = 42). Results: First, we found decreased FC between the anterior and posterior parts of the cingulum in manic patients when compared to depressed patients and HC. Second, we observed decreased SC of the cingulum bundle, particularly in its anterior part, in manic patients when compared to HC. Finally, alterations in the cingulum FC (but not SC) correlated with clinical severity scores while changes in the cingulum SC (but not FC) were related with neurocognitive deficits in sustained attention in BD. Conclusion: We demonstrate for the first time a reduction in FC and concomitantly in SC of the cingulum in mania, which correlated with psychopathological and neurocognitive parameters, respectively, in BD. This supports the central role of cingulum connectivity specifically in mania.

Original languageEnglish
Pages (from-to)339-349
Number of pages11
JournalActa Psychiatrica Scandinavica
Volume134
Issue number4
DOIs
Publication statusPublished - Oct 1 2016

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Diffusion Tensor Imaging
Bipolar Disorder
Magnetic Resonance Imaging

Keywords

  • affective disorders
  • bipolar disorder
  • magnetic resonance imaging
  • neuroimaging

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Abnormal functional–structural cingulum connectivity in mania : combined functional magnetic resonance imaging-diffusion tensor imaging investigation in different phases of bipolar disorder. / Martino, M.; Magioncalda, P.; Saiote, C.; Conio, B.; Escelsior, A.; Rocchi, G.; Piaggio, N.; Marozzi, V.; Huang, Z.; Ferri, F.; Amore, M.; Inglese, M.; Northoff, Georg.

In: Acta Psychiatrica Scandinavica, Vol. 134, No. 4, 01.10.2016, p. 339-349.

Research output: Contribution to journalArticle

Martino, M, Magioncalda, P, Saiote, C, Conio, B, Escelsior, A, Rocchi, G, Piaggio, N, Marozzi, V, Huang, Z, Ferri, F, Amore, M, Inglese, M & Northoff, G 2016, 'Abnormal functional–structural cingulum connectivity in mania: combined functional magnetic resonance imaging-diffusion tensor imaging investigation in different phases of bipolar disorder', Acta Psychiatrica Scandinavica, vol. 134, no. 4, pp. 339-349. https://doi.org/10.1111/acps.12596
Martino, M. ; Magioncalda, P. ; Saiote, C. ; Conio, B. ; Escelsior, A. ; Rocchi, G. ; Piaggio, N. ; Marozzi, V. ; Huang, Z. ; Ferri, F. ; Amore, M. ; Inglese, M. ; Northoff, Georg. / Abnormal functional–structural cingulum connectivity in mania : combined functional magnetic resonance imaging-diffusion tensor imaging investigation in different phases of bipolar disorder. In: Acta Psychiatrica Scandinavica. 2016 ; Vol. 134, No. 4. pp. 339-349.
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