Abnormal cardiac autonomic regulation in mice lacking ASIC3

Ching Feng Cheng, Terry B J Kuo, Wei Nan Chen, Chao Chieh Lin, Chih Cheng Chen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Integration of sympathetic and parasympathetic outflow is essential in maintaining normal cardiac autonomic function. Recent studies demonstrate that acid-sensing ion channel 3 (ASIC3) is a sensitive acid sensor for cardiac ischemia and prolonged mild acidification can open ASIC3 and evoke a sustained inward current that fires action potentials in cardiac sensory neurons. However, the physiological role of ASIC3 in cardiac autonomic regulation is not known. In this study, we elucidate the role of ASIC3 in cardiac autonomic function using Asic3 -/- mice. Asic3 -/- mice showed normal baseline heart rate and lower blood pressure as compared with their wild-type littermates. Heart rate variability analyses revealed imbalanced autonomic regulation, with decreased sympathetic function. Furthermore, Asic3 -/- mice demonstrated a blunted response to isoproterenol-induced cardiac tachycardia and prolonged duration to recover to baseline heart rate. Moreover, quantitative RT-PCR analysis of gene expression in sensory ganglia and heart revealed that no gene compensation for muscarinic acetylcholines receptors and beta-adrenalin receptors were found in Asic3 -/- mice. In summary, we unraveled an important role of ASIC3 in regulating cardiac autonomic function, whereby loss of ASIC3 alters the normal physiological response to ischemic stimuli, which reveals new implications for therapy in autonomic nervous system-related cardiovascular diseases.

Original languageEnglish
Article number709159
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014
Externally publishedYes

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Acid Sensing Ion Channels
Heart Rate
Sensory Ganglia
Acidification
Autonomic Nervous System
Blood pressure
Neurology
Muscarinic Receptors
Sensory Receptor Cells
Isoproterenol
Gene expression
Tachycardia
Adrenergic Receptors
Action Potentials
Neurons
Mouse Accn3 protein
Fires
Cardiovascular Diseases
Ischemia
Genes

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Abnormal cardiac autonomic regulation in mice lacking ASIC3. / Cheng, Ching Feng; Kuo, Terry B J; Chen, Wei Nan; Lin, Chao Chieh; Chen, Chih Cheng.

In: BioMed Research International, Vol. 2014, 709159, 2014.

Research output: Contribution to journalArticle

Cheng, Ching Feng ; Kuo, Terry B J ; Chen, Wei Nan ; Lin, Chao Chieh ; Chen, Chih Cheng. / Abnormal cardiac autonomic regulation in mice lacking ASIC3. In: BioMed Research International. 2014 ; Vol. 2014.
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