Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells

Jen Hui Tsou, Kung Chao Chang, Pey Yi Chang-Liao, Shu Ting Yang, Chung Ta Lee, Ya Ping Chen, Yi Chao Lee, Bo Wen Lin, Jenq Chang Lee, Meng Ru Shen, Chin Kai Chuang, Wen Chang Chang, Ju Ming Wang, Liang Yi Hung

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Over-expression of AURKC has been detected in human colorectal cancers, thyroid carcinoma and several cancer cell lines. However, the regulation and clinical implications of over-expressed AURKC in cancer cells are unclear. Here we show that elevated AURKC increases the proliferation, transformation and migration of cancer cells. Importantly, the kinase activity of AURKC is required for these tumour-associated properties. Analysis of human cancer specimens shows that the expression of AURKC is increased in cervical cancer, and is highly correlated with staging in colorectal cancer. Over-expressed AURKC-GFP localizes to the centromeric regions of mitotic chromosomes and results in a decreased level of AURKB, a key regulator of spindle checkpoint. Expression of AURKC is down-regulated by PLZF, a transcriptional repressor, through recruitment to its promoter region. The expression levels of PLZF and AURKC mRNA display opposite patterns in human cervical and colorectal cancers. Taken together, our results provide important insights into human cancers with AURKC expression, which may serve as a potential target for cancer therapy in the future.

Original languageEnglish
Pages (from-to)243-254
Number of pages12
JournalJournal of Pathology
Volume225
Issue number2
DOIs
Publication statusPublished - Oct 2011

Keywords

  • AURKC
  • cervical cancer
  • colorectal cancer
  • PLZF
  • transformation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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