Aberrant activation of the TNF-α system and production of fas and scavenger receptors on monocytes in patients with end-stage renal disease

Chia Chao Wu, Jin Shuen Chen, Shih Hua Lin, Pauling Chu, Yuh Feng Lin, Su Mei Lin, Tung Nan Liao

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Ten patients with nondialyzed chronic renal failure (CRF), 14 receiving continuous ambulatory peritoneal dialysis (CAPD), 16 receiving hemodialysis (HD), and 10 normal controls (NC), were evaluated. Levels of Fas antigen (CD95), scavenger receptors (CD36 and CD68), and tumor necrosis factor-receptor 2 (CD120b) on monocytes were measured using flow cytometry. All patients showed lymphocytopenia, and monocyte counts were decreased in those with CRE Fas levels were higher in patients receiving HD than the others, and were higher in the CRF and CAPD groups than in controls. CD120b levels were similar to those of Fas. Monocyte CD36 levels in the dialysis groups were significantly higher than in the CRF and NC groups. CD68 was also significantly elevated in HD patients. Fas levels were positively correlated with those of CD120b and CD68. The patient groups showed higher levels of apoptotic markers and scavenger receptors, combined with activation of the TNF-α system, especially in patients receiving HD.

Original languageEnglish
Pages (from-to)701-707
Number of pages7
JournalArtificial Organs
Volume29
Issue number9
DOIs
Publication statusPublished - Sep 2005
Externally publishedYes

Keywords

  • Apoptosis
  • End-stage renal disease
  • Fas
  • Scavenger receptor
  • Tumor necrosis factor alpha

ASJC Scopus subject areas

  • Biophysics

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