A young female with Spitzer-Weinstein syndrome diagnosed by thiazide test

Cheng Hao Weng, Jen Wei Cheng, Chen Chieh Hung, Mai Szu Wu, Chih Wei Yang, Chiz Tzung Chang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Spitzer-Weinstein syndrome is a rare disorder characterized by thiazide responsive hyperkalemia and normal anion gap metabolic acidosis, similar to Gordon syndrome. The hyperfunction of thiazide-sensitive Na+-Cl- cotransporter (TSC) is the main pathophysiological mechanism. We presented a 19-year-old female with short stature, normal blood pressure, persistently elevated serum potassium, and metabolic acidosis. The diagnosis of Spitzer-Weinstein Syndrome was made by clinical pictures and thiazide test. After taking 4 mg hydrochlorothiazide, her daily urine potassium excretion increased from 18.1 mmol to 41.8 mmol, urine pH decreased from 7.32 to 6.50, and urinary net charge decreased from 65.7 to 54.4. This patient then took hydrochlorothiazide 4 mg daily. The persistent hyperkalemia and metabolic acidosis were corrected. Thiazide, a powerful inhibitor of TSC, proved to be a useful tool for the diagnosis and treatment of Spitzer-Weinstein syndrome.

Original languageEnglish
Pages (from-to)239-241
Number of pages3
JournalRenal Failure
Volume29
Issue number2
DOIs
Publication statusPublished - Feb 2007
Externally publishedYes

Fingerprint

Thiazides
Acidosis
Hyperkalemia
Hydrochlorothiazide
Potassium
Urine
Acid-Base Equilibrium
Blood Pressure
Serum
Therapeutics

Keywords

  • Gordon Syndrome
  • Hyperkalemia
  • Hypertension
  • Spitzer-Weinstein Syndrome

ASJC Scopus subject areas

  • Nephrology

Cite this

Weng, C. H., Cheng, J. W., Hung, C. C., Wu, M. S., Yang, C. W., & Chang, C. T. (2007). A young female with Spitzer-Weinstein syndrome diagnosed by thiazide test. Renal Failure, 29(2), 239-241. https://doi.org/10.1080/08860220601100510

A young female with Spitzer-Weinstein syndrome diagnosed by thiazide test. / Weng, Cheng Hao; Cheng, Jen Wei; Hung, Chen Chieh; Wu, Mai Szu; Yang, Chih Wei; Chang, Chiz Tzung.

In: Renal Failure, Vol. 29, No. 2, 02.2007, p. 239-241.

Research output: Contribution to journalArticle

Weng, CH, Cheng, JW, Hung, CC, Wu, MS, Yang, CW & Chang, CT 2007, 'A young female with Spitzer-Weinstein syndrome diagnosed by thiazide test', Renal Failure, vol. 29, no. 2, pp. 239-241. https://doi.org/10.1080/08860220601100510
Weng, Cheng Hao ; Cheng, Jen Wei ; Hung, Chen Chieh ; Wu, Mai Szu ; Yang, Chih Wei ; Chang, Chiz Tzung. / A young female with Spitzer-Weinstein syndrome diagnosed by thiazide test. In: Renal Failure. 2007 ; Vol. 29, No. 2. pp. 239-241.
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